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Art. -Nr.: HY-153731

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USP1-IN-4

USP1-IN-4 (compound 10) is an effective USP1 inhibitor with an IC₅₀ value of 2.44 nM. USP1-IN-4 has anticancer activity and synergistic activity with various anticancer drugs.

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CAS. Nr.: 2878441-72-4
Formel: C₂₆H₂₃F₃N₆
Molecular Weight:476.50

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

USP1-IN-4 Chemical Structure

CAS. Nr.: 2878441-72-4

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Preis

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Protokoll (1)
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

USP1-IN-4 (compound 10) is an effective USP1 inhibitor with an IC₅₀ value of 2.44 nM. USP1-IN-4 has anticancer activity and synergistic activity with various anticancer drugs^[1].

IC₅₀ & Target

USP1

2.44 nM (IC₅₀)

Alle Deubiquitinase Isoform-spezifische Produkte anzeigen :

In Vitro

USP1-IN-4 (0.0005-10 μM, 15 min) inhibits USP1/UAF1 significantly with an IC₅₀ value of 2.44 nM^[1].
USP1-IN-4 (0.0005-10 μM, 7 days) inhibits the growth of MDA-MB-436 significantly with an IC₅₀ value of 103.75 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Cell Viability Assay^[1]

View Protocol

Cell Line:

MDA-MB-436
Concentration:

0.0005-10 μM
Incubation Time:

7 days
Result:

Inhibited cell growth with an IC₅₀ of 103.75 nM.

Chemical Information

CAS. Nr. 2878441-72-4
Molecular Weight 476.50
Formel C₂₆H₂₃F₃N₆
SMILES

FC(F)(C1=CN(C)C(C2=CC=C(CC3=NC=C4C=NC(C5=C(C(C)C)C=CC=C5)=NN43)C=C2)=N1)F
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Protokoll

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Cai S, et al. Nitrogen-containing fused heteroaromatic bicyclic compounds as USP1 inhibitors and the use thereof. China,WO 2022/253188 A.2022-8-12.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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