Valerate sodium
Based on 1 Customer Validation
Valerate sodium is the sodium salt of valeric acid, a short-chain fatty acid, and exhibits oral activity. Valerate sodium reduces binge ethanol intake and decreases blood ethanol concentration in mice, while also exerting anxiolytic effects. Valerate sodium increases GABA levels, regulates epigenetics and alters gut microbiome function. Valerate sodium can be used in research related to excessive alcohol consumption.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 98.0%
- CAS. Nr.: 6106-41-8
- Formel: C5H9NaO2
- Molecular Weight:124.11
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Speicherung:
Store at room temperature, keep dry and cool.
In solvent -80°C, 1 year , -20°C, 6 months
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6J (male, 6-8 weeks old)[1]
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Dosage:200 mM
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Administration:p.o.; daily; 10 consecutive days
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Result:Reduced ethanol consumption by 40%.
Lowered blood ethanol concentration by 53%.
Increased percentage of time spent in the center of the open field and number of center entries, with no change in total distance traveled.
Elevated GABA levels in stool and amygdala.
Increased H4 histone acetylation in the amygdala.
Induced significant changes in amygdala gene expression, including upregulation of Kcna10, Pln, and Gpr56, and downregulation of Ptgs2, Mapks, and Gpr158; associated pathways included glutamate degradation, L-DOPA degradation, and anti-inflammatory effects.
Altered gut microbiome composition, with increased abundance of genera Ileibacterium and Dubosiella; reduced gut-brain module activity for GABA degradation and 7 other neuroactive compound pathways.
No significant effects on body weight, food intake, or fluid intake compared to controls.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS. Nr. 6106-41-8
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Appearance Solid
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Molecular Weight 124.11
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Formel C5H9NaO2
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Color White to off-white
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SMILES
O=C(O[Na])CCCC
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Store at room temperature, keep dry and cool
In solvent -80°C 1 year -20°C 6 months
Lösungsmittel & Löslichkeit
H2O : 200 mg/mL (1611.47 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (269 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 8.0574 mL | 40.2868 mL | 80.5737 mL | 201.4342 mL |
| 5 mM | 1.6115 mL | 8.0574 mL | 16.1147 mL | 40.2868 mL | |
| 10 mM | 0.8057 mL | 4.0287 mL | 8.0574 mL | 20.1434 mL | |
| 15 mM | 0.5372 mL | 2.6858 mL | 5.3716 mL | 13.4289 mL | |
| 20 mM | 0.4029 mL | 2.0143 mL | 4.0287 mL | 10.0717 mL | |
| 25 mM | 0.3223 mL | 1.6115 mL | 3.2229 mL | 8.0574 mL | |
| 30 mM | 0.2686 mL | 1.3429 mL | 2.6858 mL | 6.7145 mL | |
| 40 mM | 0.2014 mL | 1.0072 mL | 2.0143 mL | 5.0359 mL | |
| 50 mM | 0.1611 mL | 0.8057 mL | 1.6115 mL | 4.0287 mL | |
| 60 mM | 0.1343 mL | 0.6714 mL | 1.3429 mL | 3.3572 mL | |
| 80 mM | 0.1007 mL | 0.5036 mL | 1.0072 mL | 2.5179 mL | |
| 100 mM | 0.0806 mL | 0.4029 mL | 0.8057 mL | 2.0143 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Valerate sodium Related Classifications
HY-W007087 Related Classifications
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