Galegenimab
Based on 1 Customer Validation
Galegenimab (FHTR 2163) is a humanized monoclonal antibody Fab fragment targeting the HtrA1 trimer. Galegenimab is used in research on age-related macular degeneration (AMD).
For research use only. We do not sell to patients.
- Purity: 99.91%
- CAS No.: 2403683-24-7
- Molecular Weight:47.71 kDa
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Fab IgG1 kappa
Human
HTRA1
As a humanized monoclonal antibody Fab fragment targeting HtrA1, Galegenimab binds to each subunit of the HtrA1 trimer with three independent Fabs to form a macromolecular complex, thereby inhibiting the protease activity of HtrA1 and blocking its proteolytic effect on extracellular matrix protein substrates such as biglycan[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
-
Fab-G1-kappa
ELISA, FACS, Functional assay
Chemical Information
-
CAS No. 2403683-24-7
-
Appearance Liquid
-
Molecular Weight 47.71 kDa
-
Color Colorless to light yellow
-
SMILES
[Galegenimab]
-
Synonyms
FHTR 2163; RG 6147; RO 7171009
-
Shipping
Shipping with dry ice.
-
Formulation
Please refer to the lot-specific COA for specific buffer information.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
-
Data Sheet (256 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Inhibitory Antibodies User Guide (603 KB)
References
[1]. Jonathan B Lin, et al. Neuroprotection for Age-Related Macular Degeneration. Ophthalmol Sci. 2022 Jul 5;2(4):100192. [Content Brief]
[2]. Eichenbaum DA, et al. Phase 2 Study of the Anti-High Temperature Requirement A1 (HtrA1) Fab Galegenimab (FHTR2163) in Geographic Atrophy Secondary to Age-Related Macular Degeneration. Am J Ophthalmol. 2025 Jul;275:14-26. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Galegenimab Related Classifications
HY-P99629 Related Classifications
Powered by Bioz