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GNGT1 - G protein subunit gamma transducin 1 Gene

Also Known as GNG1; HG3G1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2792

About GNGT1

Cytogenetic location: 7q21.3 Genomic coordinates (GRCh38): 7:93,906,567-93,911,265 (from NCBI)

This gene has 5 transcripts (splice variants), 143 orthologues and 11 paralogues. Restricted expression toward placenta (RPKM 1.6).

Summary

This gene encodes the gamma subunit of transducin, a guanine nucleotide-binding protein (G protein) that is found in rod outer segments. Transducin, also known as GMPase, mediates the activation of a cyclic GTP-specific (guanosine monophosphate) phosphodiesterase by rhodopsin. [provided by RefSeq, Jul 2016]

GNGT1 Products (2)

mRNA	Protein	Name
NM_001329426.2	NP_001316355.1	guanine nucleotide-binding protein G(T) subunit gamma-T1 precursor
NM_021955.5	NP_068774.1	guanine nucleotide-binding protein G(T) subunit gamma-T1 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GNGT1 Protein Structure

G-gamma

0
74 a.a.

Protein Preferred Names	Protein Names
guanine nucleotide-binding protein G(T) subunit gamma-T1	guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1

GNGT1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	GNGT1	P63211	ZNF277	Homo sapiens	Q8WWA6	Y2H Prey Pooling	25416956
Intra	GNGT1	P63211	ZNF277	Homo sapiens	G5E9M4	Y2H Prey Pooling	32296183
Intra	GNGT1	P63211	ZNF277	Homo sapiens	G5E9M4	Y2H Array	32296183
Intra	GNGT1	P63211	PDCL	Homo sapiens	Q13371	Anti Tag CoIP	33961781
Intra	GNGT1	P63211	UBXN4	Homo sapiens	Q92575	Y2H Prey Pooling	32296183
Intra	GNGT1	P63211	UBXN4	Homo sapiens	Q92575	Validated Y2H	32296183
Intra	GNGT1	P63211	UBXN4	Homo sapiens	Q92575	Y2H Array	32296183
Intra	GNGT1	P63211	GORASP2	Homo sapiens	Q9H8Y8	Validated Y2H	32296183
Intra	GNGT1	P63211	GORASP2	Homo sapiens	Q9H8Y8	Y2H Prey Pooling	32296183
Intra	GNGT1	P63211	GORASP2	Homo sapiens	Q9H8Y8	Y2H Array	32296183
Intra	GNGT1	P63211	MSANTD4	Homo sapiens	Q8NCY6	Validated Y2H	32296183
Intra	GNGT1	P63211	MSANTD4	Homo sapiens	Q8NCY6	Y2H Array	32296183
Intra	GNGT1	P63211	MSANTD4	Homo sapiens	Q8NCY6	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant GNGT1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76369	GNGT1 Protein, Human (His)	P63211 (P2-C71)	≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Night Blindness, Congenital Stationary, Autosomal Dominant 2	Congenital Stationary Night Blindness Autosomal Dominant 2 CSNBAD2 Hemeralopia Night Blindness, Congenital Stationary, Rambusch Type Rambusch Type Congenital Stationary Night Blindness Congenital Stationary Night Blindness Rambusch Type Hemeralopia Congenital Essential Blindness, Night, Stationary, Congenital, Autosomal Dominant, Type 2
Leber Plus Disease	Leber Congenital Amaurosis Lca Leber'S Amaurosis Leber'S Disease Amaurosis Congenita Of Leber Amaurosis Congenita Of Leber, Type 1 Lhon Plus Disease Congenital Absence Of The Rods And Cones Congenital Retinal Blindness Crb Congenital Amaurosis Of Retinal Origin Leber'S Congenital Amaurosis Leber Congenital Amaurosis 1 Leber'S Congenital Tapetoretinal Degeneration Leber'S Congenital Tapetoretinal Dysplasia Lca1 Leber Congenital Amaurosis Type 1 Retinal Blindness, Congenital Amaurosis, Leber Congenital Dysgenesis Neuroepithelialis Retinae Hereditary Epithelial Dysplasia Of Retina Hereditary Retinal Aplasia Heredoretinopathia Congenitalis Leber Abiotrophy Leber Congenital Tapetoretinal Degeneration Lebers Congenital Amaurosis Optic Atrophy, Hereditary, Leber
Fundus Dystrophy	Retinal Dystrophy Retinal Dystrophies Dystrophy, Retinal
Cone-Rod Dystrophy 2	Cone-Rod Dystrophy CORD2 Cone-Rod Retinal Dystrophy Rcrd2 Cone-Rod Retinal Dystrophy 2 Crd2 Cord Crd Retinal Cone-Rod Dystrophy Cone-Rod Retinal Dystrophy-2 Retinal Cone-Rod Dystrophy 2 Tapetoretinal Degeneration Cone-Rod Degeneration Cone Rod Dystrophy Dystrophy, Cone-Rod Dystrophy, Cone-Rod, Type 2 Retinitis Pigmentosa Retinitis Pigmentosa 2 Progressive Cone-Rod Dystrophy
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05562	GNGT1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19436	Gngt1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25927	Gngt1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	GNGT1	VGNC	VGNC:73098
Mus musculus	GNGT1	MGD	MGI:109165
Felis catus	GNGT1	VGNC	VGNC:62624
Bos taurus	GNGT1	VGNC	VGNC:29470
Rattus norvegicus	GNGT1	RGD	RGD:1595475
Canis familiaris	GNGT1	VGNC	VGNC:41324
Others	GNGT1	NCBI