GRM3 - glutamate metabotropic receptor 3 Gene

Also Known as GLUR3; mGlu3; GPRC1C; MGLUR3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 2913

About GRM3

Cytogenetic location: 7q21.11-q21.12 Genomic coordinates (GRCh38): 7:86,643,909-86,864,879 (from NCBI)

This gene has 5 transcripts (splice variants), 215 orthologues, 7 paralogues and is associated with 88 phenotypes. Restricted expression toward brain (RPKM 15.9).

Summary

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and Metabotropic Glutamate Receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The Metabotropic Glutamate Receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate Phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. [provided by RefSeq, Jul 2008]

GRM3 Products (4)

mRNA Protein Name
XM_017012073.3 XP_016867562.1 metabotropic glutamate receptor 3 isoform X2
XM_047420268.1 XP_047276224.1 metabotropic glutamate receptor 3 isoform X1
NM_000840.3 NP_000831.2 metabotropic glutamate receptor 3 isoform 1 precursor
NM_001363522.2 NP_001350451.1 metabotropic glutamate receptor 3 isoform 2 precursor

GRM3 Protein Structure

ANF_receptor

ANF_receptor: Receptor family ligand binding region (67 - 470)

NCD3G

NCD3G: Nine Cysteines Domain of family 3 GPCR (505 - 555)

7tm_3

7tm_3: 7 transmembrane sweet-taste receptor of 3 GCPR (586 - 826)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 879 a.a.
Protein Preferred Names Protein Names

metabotropic glutamate receptor 3

  • glutamate receptor, metabotropic 3

GRM3 Antibodies

Cat. No. Product Name Application Reactivity
HY-P83232 Metabotropic Glutamate Receptor 3 Antibody (YA2977) WB Human, Mouse, Rat
HY-P84578 Metabotropic Glutamate Receptor 3 Antibody (YA4275) IHC-P, ICC/IF, FC, ELISA Human
HY-P84578A Metabotropic Glutamate Receptor 3 Antibody (YA4275)(PBS only) IHC-P, ICC/IF, FC, ELISA Human

Related Diseases

Diseases Alias
Status Epilepticus

  • Grand Mal Status Epilepticus

  • Grand Mal Status

  • Gcse

  • Generalized Convulsive Status Epilepticus

  • Se

  • Epilepsy With Status Epilepticus
Psychotic Disorder

  • Psychotic Disorders

  • Mental Or Behavioural Disorder

  • Psychotic

  • Mental Disorders
Schizophrenia

  • SCZD

  • Schizophrenia With Or Without An Affective Disorder

  • Schizophrenia 12

  • Schizophrenia, Susceptibility To

  • Schizophrenia-1

  • Dementia Praecox

  • Schizophrenia 1
Major Depressive Disorder

  • Seasonal Affective Disorder

  • Unipolar Depression

  • Depression

  • MDD

  • Depressive Disorder

  • Unipolar Depression, Susceptibility To

  • Major Depressive Disorder 1

  • Major Depressive Disorder, Response To Citalopram Therapy In

  • Major Depressive Disorder 2

  • Winter Depression

  • Single Major Depressive Episode

  • Sad

  • Clinical Depression

  • Major Depression

  • Depressive Syndrome

  • Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment

  • Seasonal Affective Disorder, Susceptibility To

  • Recurrent Major Depression

  • Affective Disorder, Seasonal

  • Depression In A Seasonal Pattern

  • Depression

  • Seasonal

  • Major Depressive Disorder With A Seasonal Pattern

  • Seasonal Depression

  • Seasonal Mood Disorder

  • Mental Depression

  • Recurrent Major Depressive Episodes
Melanoma

  • Malignant Melanoma

  • Cutaneous Melanoma

  • Naevocarcinoma

  • Malignant Melanomas
Huntington Disease

  • Huntington'S Disease

  • Huntington Chorea

  • HD

  • Huntington'S Chorea

  • Huntington Chronic Progressive Hereditary Chorea

  • Juvenile Huntington Disease

  • Chronic Progressive Chorea

  • Chronic Progressive Hereditary Chorea

  • Hc - [Huntington Chorea]

  • Hereditary Chorea

  • Progressive Hereditary Chorea
Schizophreniform Disorder

  • Schizophreniform Disorders

  • Psychotic Disorders
Epilepsy

  • Epilepsy Syndrome

  • Epileptic Syndrome

  • Epilepsies

  • Symptomatic Epilepsies

  • Post Traumatic Epilepsy

  • Traumatic Epilepsy

  • Traumatic Epileptic

  • Epilepsy Due To Hippocampal Sclerosis

  • Epilepsy With Ammon'S Horn Sclerosis

  • Epilepsy Due To Cortical Dysplasia

  • Epilepsy Due To Neuronal Migration Disorders
Bipolar Disorder

  • Bipolar Depression

  • Manic Disorder

  • Depression, Bipolar

  • Bipolar Disorder Manic Phase

  • Depressive-Manic Psych.

  • Manic Bipolar Affective Disorder

  • Manic Bipolar I Disorder

  • Manic Depression

  • Manic Depressive Disorder

  • Mixed Bipolar Disorder

  • Bipolar Affective Disorder

  • Bipolar Affective Psychosis

  • Bipolar Spectrum Disorder

  • Manic Depressive Illness

  • Depression Bipolar

  • Bipolar Disorder, Mixed

  • Major Affective Disorder

  • Major Affective Disorder 1

  • Major Affective Disorder 2
Attention Deficit-Hyperactivity Disorder

  • Attention Deficit Hyperactivity Disorder

  • ADHD

  • Attention Deficit Disorder

  • Attention Deficit-Hyperactivity Disorder, Susceptibility To

  • Attention Deficit Disorder With Hyperactivity

  • Hyperkinetic Disorder

  • Hyperactivity Of Childhood

  • Attention-Deficit/Hyperactivity Disorder

  • Add

  • Addh

  • Attention Deficit

  • Attention Deficit Disorder Of Childhood With Hyperactivity

  • Attention Deficit Disorder With Hyperactivity Syndrome

  • Hyperkinetic Syndrome

  • Attention-Deficit Hyperactivity Disorder

  • Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type

  • Disturbance Of Activity And Attention

  • Disorder Of Activity And Attention

  • Adhd - [Attention Deficit Hyperactivity Disorder]

  • Hyperkinetic Disorders

  • Disorder Of Activity And Attention With Hyperkinesia

  • Attention Deficit Syndrome With Hyperactivity
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05825 GRM3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05826 Grm3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05827 Grm3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus GRM3 VGNC VGNC:29660
Rattus norvegicus GRM3 RGD RGD:2744
Macaca mulatta GRM3 VGNC VGNC:73287
Mus musculus GRM3 MGD MGI:1351340
Canis familiaris GRM3 VGNC VGNC:41510
Felis catus GRM3 VGNC VGNC:67478