Averythrin
Averythrin is an antibacterial agent that can be used in studies related to Staphylococcus aureus infections.
For research use only. We do not sell to patients.
- CAS No.: 25340-85-6
- Formula: C20H18O6
- Molecular Weight:354.36
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| H9c2 | IC50 |
62.1 μM
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Cytotoxicity against normal rat H9c2 cardiomyocytes assessed as reduction in cell viability after 24 h incubation by MTT assay.
Cytotoxicity against normal rat H9c2 cardiomyocytes assessed as reduction in cell viability after 24 h incubation by MTT assay.
|
41123691 |
| MCF7 | IC50 |
29.69 μM
Compound: 15
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Cytotoxicity against human MCF7 cells after 72 hrs BY SRB assay
Cytotoxicity against human MCF7 cells after 72 hrs BY SRB assay
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[PMID: 22703109] |
| HaCaT | IC50 |
56.5 μM
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Cytotoxicity against normal human HaCaT keratinocytes assessed as reduction in cell viability after 24 h incubation by MTT assay.
Cytotoxicity against normal human HaCaT keratinocytes assessed as reduction in cell viability after 24 h incubation by MTT assay.
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41123691 |
| NCI-H460 | IC50 |
50 μM
Compound: 15
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Cytotoxicity against human NCI-H460 cells after 72 hrs BY SRB assay
Cytotoxicity against human NCI-H460 cells after 72 hrs BY SRB assay
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[PMID: 22703109] |
| H9c2 | IC50 |
61.5 μM
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Cytotoxicity against normal rat H9c2 cardiomyocytes assessed as reduction in cell viability after 48 h incubation by MTT assay.
Cytotoxicity against normal rat H9c2 cardiomyocytes assessed as reduction in cell viability after 48 h incubation by MTT assay.
|
41123691 |
| SF-268 | IC50 |
50 μM
Compound: 15
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Cytotoxicity against human SF268 cells after 72 hrs BY SRB assay
Cytotoxicity against human SF268 cells after 72 hrs BY SRB assay
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[PMID: 22703109] |
| HaCaT | IC50 |
57.1 μM
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Cytotoxicity against normal human HaCaT keratinocytes assessed as reduction in cell viability after 48 h incubation by MTT assay.
Cytotoxicity against normal human HaCaT keratinocytes assessed as reduction in cell viability after 48 h incubation by MTT assay.
|
41123691 |
In Vitro
Averythrin (compound 7) (1.563-100 μM; 18 h) potently inhibits Staphylococcus aureus growth and biofilm formation with IC50 values of 11.36 μM and 10.66 μM, respectively[2].
Averythrin (up to 100 μM; 24-48 h) exhibits moderate, time-stable cytotoxicity to normal H9c2 cardiomyocytes and HaCaT keratinocytes, with IC50 values ranging from 56.5 μM to 62.1 μM across 24 h and 48 h incubations[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
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Cell Line:normal rat H9c2 cardiomyocytes, normal human HaCaT keratinocytes
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Concentration:up to 100 μM
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Incubation Time:24 h, 48 h
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Result:Exhibited moderate cytotoxicity to H9c2 cells with an IC50 of 62.1 μM after 24 h incubation.
Exhibited moderate cytotoxicity to HaCaT cells with an IC50 of 56.5 μM after 24 h incubation.
Exhibited moderate cytotoxicity to H9c2 cells with an IC50 of 61.5 μM after 48 h incubation.
Exhibited moderate cytotoxicity to HaCaT cells with an IC50 of 57.1 μM after 48 h incubation.
Chemical Information
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CAS No. 25340-85-6
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Molecular Weight 354.36
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Formula C20H18O6
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SMILES
O=C1C=2C(C(=O)C=3C1=C(O)C=C(O)C3)=CC(O)=C(/C=C/CCCC)C2O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Research Protocol for Infectious Diseases
Infectious-disease experiments test how pathogens interact with host barriers, innate immune receptors, inflammatory signaling, pathogen replication, and tissue injury; pattern-recognition receptors such as TLRs, RIG-I-like receptors, NOD-like receptors, and inflammasomes detect microbial molecules and activate NF-κB, interferon, and cytokine responses. The central hypothesis is that infection severity reflects the balance between pathogen burden and host response: protective inflammation restricts pathogen growth, whereas excessive or mislocalized inflammation contributes to tissue damage and disease phenotype. Unresolved questions include which host pathways are protective versus pathogenic, why some infection models fail to translate to human disease, and which combined readouts best predict clinically relevant infection outcomes.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Averythrin Related Classifications
HY-187651 Related Classifications
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