AZ'320
AZ'320 is an ATP-competitive necroptosis (EC50 of 4.9 μM) inhibitor and a RIPK1 (pKD of 5.45) inhibitor. AZ'320 inhibits necroptosis by inhibiting RIPK1 phosphorylation. AZ’320 prevents mortality of the mice and rescues temperature and body weight in SIRS mice models. AZ'320 can be used for researches of cancer and inflammation.
For research use only. We do not sell to patients.
- Formula: C20H20N2O4S2
- Molecular Weight:416.51
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
AZ’320 (0.1-10 μM, 4 h) dose-dependently inhibits the levels of RIPK1 Ser166 phosphorylation in I2.1 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:I2.1 FADD−/− human Jurkat cells
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Concentration:01, 1, 5 and 10 μM
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Incubation Time:4 h
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Result:Dose-dependently inhibited the levels of RIPK1 Ser166 phosphorylation.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Systemic inflammatory response syndrome (SIRS) mice models (C57BL/6, male, 6-8 weeks)[1]
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Dosage:5 mg/kg
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Administration:Intravenously injection, 15 min before 96 h of 0.5 mg/kg TNF stimulation
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Result:Prevented mortality of the mice and rescued temperature and body weight to a similar degree as Nec-1 (HY-15760).
Chemical Information
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Molecular Weight 416.51
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Formula C20H20N2O4S2
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SMILES
O=S(C1=CC=C(C2=CC=C3C=CC=NC3=C2)C=C1)(N4CC(CS(=O)(C)=O)C4)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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