AZ-GHS-22
AZ-GHS-22 is a potent, non-CNS penetrant GHS-R1a inverse agonist (IC50=0.77 nM).
For research use only. We do not sell to patients.
- CAS No.: 1143020-91-0
- Formula: C27H33ClN6O5S2
- Molecular Weight:621.17
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | IC50 |
0.77 nM
Compound: 22
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Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method
Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method
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[PMID: 24967667] |
| HEK293 | IC50 |
1.1 nM
Compound: 22
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Displacement of [125I]human ghrelin from mouse GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method
Displacement of [125I]human ghrelin from mouse GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method
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[PMID: 24967667] |
| HEK293 | IC50 |
3.4 nM
Compound: 22
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Displacement of [125I]human ghrelin from rat GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method
Displacement of [125I]human ghrelin from rat GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method
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[PMID: 24967667] |
Chemical Information
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CAS No. 1143020-91-0
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Molecular Weight 621.17
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Formula C27H33ClN6O5S2
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SMILES
O=C(NC(NC1=NC2=CC=C(S(=O)(CCCN3CCN(C)CC3)=O)C=C2S1)=O)C4=CC(N5CCOCC5)=CC=C4Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AZ-GHS-22 Related Classifications
HY-137061 Related Classifications
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