Azithromycin-d₃

Name: Azithromycin-d 3
Brand: MedChemExpress
SKU: HY-17506S
Rating: 5.0 (0 reviews)

製品番号: HY-17506S 純度: 98.0%: Data Sheet SDS COA 取扱説明書
FAQs
Technical Support

Azithromycin-d₃ is the deuterium labeled Azithromycin. Azithromycin (CP-62993) is a macrolide antibiotic useful for the treatment of a number of bacterial infections.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

Azithromycin-d₃ 構造式

CAS 番号 : 163921-65-1

容量	価格（税別）	在庫状況	数量
1 mg	$480	在庫あり	Estimated Time of Arrival: December 31
5 mg	$1200	在庫あり	Estimated Time of Arrival: December 31
10 mg		お問い合わせ
50 mg		お問い合わせ

or バルクお問い合わせ

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 0 publication(s) in Google Scholar

Other Forms of Azithromycin-d₃:

Azithromycin 在庫あり
Azithromycin hydrate 在庫あり

Antibiotic アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

生物活性
純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

Azithromycin-d₃ is the deuterium labeled Azithromycin. Azithromycin (CP-62993) is a macrolide antibiotic useful for the treatment of a number of bacterial infections^[1]^[2].

Application

1. This compound can be used as a tracer.
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

IC₅₀ & Target

Macrolide

体外実験

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

752.00

分子式

C₃₈H₆₉D₃N₂O₁₂

CAS 番号

163921-65-1

Unlabeled CAS

83905-01-5

Appearance

Solid

Color

White to light yellow

SMILES

C[C@H]([C@@H](O[C@@]([H])([C@@H]1O)O[C@@H](C[C@@H]1N(C)C)C)[C@](C[C@@H](C)CN2C([2H])([2H])[2H])(C)O)[C@H](O[C@@]([H])(C[C@]3(OC)C)O[C@H]([C@@H]3O)C)[C@@H](C)C(O[C@@H]([C@@](O)([C@@H]([C@H]2C)O)C)CC)=O

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶剤 & 溶解度

体外:

Ethanol : ≥ 100 mg/mL (132.98 mM)

DMSO : 100 mg/mL (132.98 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.3298 mL	6.6489 mL	13.2979 mL
5 mM	0.2660 mL	1.3298 mL	2.6596 mL
10 mM	0.1330 mL	0.6649 mL	1.3298 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

純度とドキュメンテーション

純度: 99.7%

Select Batch:

データシート (283 KB) SDS (252 KB)

COA (267 KB) Elemental Analysis Report (123 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Menzel M, et al. Azithromycin augments rhinovirus-induced IFNβ via cytosolic MDA5 in experimental models of asthma exacerbation. Oncotarget. 2017 Mar 18. [Content Brief]

[3]. Vandooren J, et al. Differential inhibition of activity, activation and gene expression of MMP-9 in THP-1 cells by azithromycin and minocycline versus bortezomib: A comparative study. PLoS One. 2017 Apr 3;12(4):e0174853. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

Ethanol / DMSO	1 mM	1.3298 mL	6.6489 mL	13.2979 mL	33.2447 mL
	5 mM	0.2660 mL	1.3298 mL	2.6596 mL	6.6489 mL
	10 mM	0.1330 mL	0.6649 mL	1.3298 mL	3.3245 mL
	15 mM	0.0887 mL	0.4433 mL	0.8865 mL	2.2163 mL
	20 mM	0.0665 mL	0.3324 mL	0.6649 mL	1.6622 mL
	25 mM	0.0532 mL	0.2660 mL	0.5319 mL	1.3298 mL
	30 mM	0.0443 mL	0.2216 mL	0.4433 mL	1.1082 mL
	40 mM	0.0332 mL	0.1662 mL	0.3324 mL	0.8311 mL
	50 mM	0.0266 mL	0.1330 mL	0.2660 mL	0.6649 mL
	60 mM	0.0222 mL	0.1108 mL	0.2216 mL	0.5541 mL
	80 mM	0.0166 mL	0.0831 mL	0.1662 mL	0.4156 mL
	100 mM	0.0133 mL	0.0665 mL	0.1330 mL	0.3324 mL