2. PROTAC
  3. PROTAC Linkers
  4. Biotin-PEG4-Picolyl azide

Biotin-PEG4-Picolyl azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Biotin-PEG4-Picolyl azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

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Biotin-PEG4-Picolyl azide Chemical Structure

Biotin-PEG4-Picolyl azide Chemical Structure

CAS No. : 2222687-71-8

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5 mg USD 330 In-stock
10 mg USD 530 In-stock
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Based on 1 publication(s) in Google Scholar

Biotin-PEG4-Picolyl azide Related Antibodies

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Description

Biotin-PEG4-Picolyl azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Biotin-PEG4-Picolyl azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

IC50 & Target

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Biotin-PEG4-Picolyl azide Related Antibodies
Molecular Weight

622.74

Formula

C27H42N8O7S
CAS No.
Appearance

Oil

Color

Colorless to off-white

SMILES

O=C(NC1=CC=C(CN=[N+]=[N-])N=C1)CCOCCOCCOCCOCCNC(CCCC[C@@H]2SC[C@]([C@]2([H])N3)([H])NC3=O)=O
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Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (200.73 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6058 mL 8.0290 mL 16.0581 mL
5 mM 0.3212 mL 1.6058 mL 3.2116 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6058 mL 8.0290 mL 16.0581 mL 40.1452 mL
5 mM 0.3212 mL 1.6058 mL 3.2116 mL 8.0290 mL
10 mM 0.1606 mL 0.8029 mL 1.6058 mL 4.0145 mL
15 mM 0.1071 mL 0.5353 mL 1.0705 mL 2.6763 mL
20 mM 0.0803 mL 0.4015 mL 0.8029 mL 2.0073 mL
25 mM 0.0642 mL 0.3212 mL 0.6423 mL 1.6058 mL
30 mM 0.0535 mL 0.2676 mL 0.5353 mL 1.3382 mL
40 mM 0.0401 mL 0.2007 mL 0.4015 mL 1.0036 mL
50 mM 0.0321 mL 0.1606 mL 0.3212 mL 0.8029 mL
60 mM 0.0268 mL 0.1338 mL 0.2676 mL 0.6691 mL
80 mM 0.0201 mL 0.1004 mL 0.2007 mL 0.5018 mL
100 mM 0.0161 mL 0.0803 mL 0.1606 mL 0.4015 mL
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Biotin-PEG4-Picolyl azide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Biotin-PEG4-Picolyl azide2222687-71-8PROTAC LinkersInhibitorinhibitorinhibit

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