Bis-Pro-5FU
Bis-Pro-5FU (Compound 4) is a 5-FU precursor that confers oral bioavailability and increase the safety profile of 5-Fluorouracil (5-FU) chemotherapy regimens. 5-FU is an antineoplastic antimetabolite that is widely used for the research of colorectal and pancreatic cancer.
For research use only. We do not sell to patients.
- CAS No.: 2155827-07-7
- Formula: C10H7FN2O2
- Molecular Weight:206.17
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| BXPC-3 | EC50 |
>100 μM
Compound: 4
|
Antiproliferative activity against human BxPC-3 cells assessed as reduction in cell viability measured after 5 days by PrestoBlue reagent based assay
Antiproliferative activity against human BxPC-3 cells assessed as reduction in cell viability measured after 5 days by PrestoBlue reagent based assay
|
[PMID: 34979089] |
| HCT-116 | EC50 |
>100 μM
Compound: 4
|
Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability measured after 5 days by PrestoBlue reagent based assay
Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability measured after 5 days by PrestoBlue reagent based assay
|
[PMID: 34979089] |
Chemical Information
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CAS No. 2155827-07-7
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Molecular Weight 206.17
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Formula C10H7FN2O2
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SMILES
FC1=CN=C(OCC#C)N=C1OCC#C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)