Butikacin
Butikacin (UK-18892) is an antibiotic and a derivative of Kanamycin (HY-16566). Butikacin resists most aminoglycoside-inactivating enzymes through its structure, thereby inhibiting bacterial growth. Butikacin can be used in research on bacterial infections.
For research use only. We do not sell to patients.
- CAS No.: 59733-86-7
- Formula: C22H45N5O12
- Molecular Weight:571.62
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
In Vitro
Butikacin (UK-18892) (overnight) exhibits potent antibacterial activity against 21 unselected clinical isolates of P. aeruginosa, with a modal MIC of 2 μg/mL[2].
Butikacin (50 μg/mL) exhibits a low protein binding rate (16.1%) in human serum[2].
Butikacin (1.25-20 μg/mL) is modified by 6'-aminoacetyltransferase in acetyltransferase preparations from Escherichia coli R5/W677[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Redfern strain (Pfizer colony) (albino, within 48 h of birth)[1]
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Dosage:50 mg/kg; 100 mg/kg; 200 mg/kg
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Administration:s.c.; once daily; up to 40 days
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Result:Had no effect on Preyer's reflex for the first 25 to 30 days, after which mean threshold sound intensities began to rise slowly at 50 mg/kg per day, .
At 100 mg/kg per day, thresholds at 12 kHz began to rise between days 12 and 15, and complete loss of Preyer's reflex at 12 kHz required 33 days.
At 200 mg/kg per day, produced rapid loss of Preyer's reflex at 12 kHz within 17 days.
Chemical Information
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CAS No. 59733-86-7
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Molecular Weight 571.62
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Formula C22H45N5O12
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SMILES
NCC[C@H](O)CN[C@H]1[C@H](O[C@@H]2[C@H](O)[C@@H](N)[C@H](O)[C@@H](CO)O2)[C@@H](O)[C@H](O[C@@H]3[C@H](O)[C@@H](O)[C@H](O)[C@@H](CN)O3)[C@@H](N)C1
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Synonyms
UK-18892
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Butikacin Related Classifications
HY-187726 Related Classifications
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Keywords
- Butikacin
- 59733-86-7
- UK-18892
- UK18892
- UK 18892
- Antibiotic
- Drug Derivative
- Bacterial
- acetyltransferase
- indole-positive Proteus spp.
- E. coli R5/W677
- S. aureus
- neonatal guinea pigs
- 1-N-[(S)-4-amino-2-hydroxybutyl]kanamycin A
- P. aeruginosa
- aminoglycoside antibiotic
- Klebsiella spp.
- Enterobacter spp.
- Inhibitor
- inhibitor
- inhibit