BVT-116429
BVT-116429 is an 11βHSD1 inhibitor with the activity of increasing adiponectin concentration and improving glucose homeostasis in diabetic mice. BVT-116429 can increase plasma adiponectin levels in diabetic KKAy mice, reduce basal insulin levels, and reduce fasting blood glucose levels after 10 days of inhibition, similar to the effect of rosiglitazone.
For research use only. We do not sell to patients.
- CAS No.: 870710-02-4
- Formula: C13H12F4N2OS
- Molecular Weight:320.31
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CHO | IC50 |
33 nM
Compound: 17
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Inhibition of human 11beta-HSD1 over expressed in CHO cells by whole cell assay
Inhibition of human 11beta-HSD1 over expressed in CHO cells by whole cell assay
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[PMID: 17266194] |
Chemical Information
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CAS No. 870710-02-4
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Molecular Weight 320.31
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Formula C13H12F4N2OS
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SMILES
C[C@@H](C1=C(C=CC=C1)F)NC(S[C@@](C)2C(F)(F)F)=NC2=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BVT-116429 Related Classifications
HY-118113 Related Classifications
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