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BVT-2733 hydrochloride

4 Cited Publications
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Based on 4 publication(s) in Google Scholar

BVT-2733 hydrochloride is a potent, selective and orally active nonsteroidal 11β-HSD1 inhibitor. BVT-2733 hydrochloride is more potent against mouse 11β-HSD1 enzyme (IC50=96 nM) than against human 11β-HSD1 enzyme (IC50=3341 nM). BVT-2733 hydrochloride has the potential to be used in the study of arthritis and obesity-related diseases.

For research use only. We do not sell to patients.

  • CAS No.: 376641-65-5
  • Formula: C17H22Cl2N4O3S2
  • Molecular Weight:465.42
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • BVT-2733 hydrochloride Chemical Structure
    BVT-2733 hydrochloride Chemical Structure
  • Experimental Validation Results for BVT-2733 hydrochloride
  • Experimental Validation Results for BVT-2733 hydrochloride
  • Experimental Validation Results for BVT-2733 hydrochloride
  • Experimental Validation Results for BVT-2733 hydrochloride
  • Experimental Validation Results for BVT-2733 hydrochloride
CAS No.: 376641-65-5
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609-228-6898
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Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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Cell Imaging/StainingWBIn Vivo Efficacy StudyIFBio/Physico-chemical Assay
  • Cell Imaging/Staining
  • In Vivo Efficacy Study
  • Bio/Physico-chemical Assay
  • WB
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  • BVT-2733 hydrochloride Chemical Structure
    BVT-2733 hydrochloride Chemical Structure
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    BVT-2733 hydrochloride purchased from MedChemExpress. Usage Cited in: Acta Pharm Sin B. 2022 May;12(5):2358-2373. [Abstract]

    Customer Validation
     Representative oil red O-stained images treated with BVT 2733 (10 μM).

  • 1/16

    BVT-2733 hydrochloride purchased from MedChemExpress. Usage Cited in: Acta Pharm Sin B. 2022 May;12(5):2358-2373. [Abstract]

    Customer Validation
     Change curves of body weight treated with vehicle, 40 mg/kg EQST or 40 mg/kg BVT.2733, respectively.

  • 1/16

    BVT-2733 hydrochloride purchased from MedChemExpress. Usage Cited in: Acta Pharm Sin B. 2022 May;12(5):2358-2373. [Abstract]

    Customer Validation
     11β-HSD1 and 11β-HSD2 enzyme activity in EQST or BVT.2733(40 mg/kg) treated 3T3-L1-derived mature adipocyte.

  • 1/16

    BVT-2733 hydrochloride purchased from MedChemExpress. Usage Cited in: Int J Biol Sci. 2022 Apr 30;18(8):3107-3121. [Abstract]

    Customer Validation
     Western blot detection of proteins related to the lipid biosynthesis, oxidation, secretion, uptake, and hydrolysis pathways in 11β-HSD1 overexpressed or GFP overexpressed Hep1-6 cells exposed or not to 0.25 μM BVT2733.

  • 1/16

    BVT-2733 hydrochloride purchased from MedChemExpress. Usage Cited in: Int J Biol Sci. 2022 Apr 30;18(8):3107-3121. [Abstract]

    Customer Validation
     Immunofluorescence staining of the distribution of GR (red) following treatment or not with 0.25 μM BVT2733 in Hep1-6 cells overexpressing 11β-HSD1 or GFP.

  • BVT-2733 hydrochloride