BVT-2733 hydrochloride
Based on 4 publication(s) in Google Scholar
BVT-2733 hydrochloride is a potent, selective and orally active nonsteroidal 11β-HSD1 inhibitor. BVT-2733 hydrochloride is more potent against mouse 11β-HSD1 enzyme (IC50=96 nM) than against human 11β-HSD1 enzyme (IC50=3341 nM). BVT-2733 hydrochloride has the potential to be used in the study of arthritis and obesity-related diseases.
For research use only. We do not sell to patients.
- CAS No.: 376641-65-5
- Formula: C17H22Cl2N4O3S2
- Molecular Weight:465.42
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Publications Citing Use of MedChemExpress (MCE) BVT-2733 hydrochloride
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Biological Activity
Chemical Information
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CAS No. 376641-65-5
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Molecular Weight 465.42
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Formula C17H22Cl2N4O3S2
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SMILES
O=S(C1=CC=CC(Cl)=C1C)(NC2=NC(CC(N3CCN(C)CC3)=O)=CS2)=O.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (4)
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Journal Impact Factor
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Most Recent
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Acta Pharm Sin B
2022 May;12(5):2358-2373. PMID: 35646525 -
Int J Biol Sci
The GR-gp78 Pathway is involved in Hepatic Lipid Accumulation Induced by Overexpression of 11β-HSD1. [Abstract]2022 Apr 30;18(8):3107-3121. PMID: 35637957 -
J Ethnopharmacol
Glycyrrhizic acid and patchouli alcohol in Huoxiang Zhengqi attenuate intestinal inflammation and barrier injury via regulating endogenous corticosterone metabolism mediated by 11β-HSD1. [Abstract]2024 Nov 1:119025. PMID: 39489360 -
Mol Med Rep
11β‑hydroxysteroid dehydrogenase‑1 is associated with the activation of hepatic stellate cells in the development of hepatic fibrosis. [Abstract]2020 Oct;22(4):3191-3200. PMID: 32945429
Purity & Documentation
References
[1]. 11β-hydroxydehydrogenase 1 (11β-HSD1) Inhibitor in Development
[2]. Zhang L, et al. 11β-Hydroxysteroid dehydrogenase 1 inhibition attenuates collagen-induced arthritis. Int Immunopharmacol. 2013 Nov;17(3):489-94. [Content Brief]
[3]. Wang L, et al. BVT.2733, a selective 11β-hydroxysteroid dehydrogenase type 1 inhibitor, attenuates obesity and inflammation in diet-induced obese mice. PLoS One. 2012;7(7):e40056. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BVT-2733 hydrochloride Related Classifications
HY-18054A Related Classifications
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