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製品番号: HY-101031

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c-Met-IN-1

c-met-IN-1 (compound 16) is a potent and selective c-Met inhibitor, with IC₅₀ of 1.1 nM, with antitumor activity..

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CAS 番号: 2084836-84-8
分子式: C₃₅H₃₇FN₆O₅
分子量:640.70

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

c-Met-IN-1 構造式

CAS 番号: 2084836-84-8

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- Cellular Effect
- 体外実験
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

c-met-IN-1 (compound 16) is a potent and selective c-Met inhibitor, with IC₅₀ of 1.1 nM, with antitumor activity.^[1].

IC₅₀ & Target

IC50: 1.1 nM (c-Met)^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	0.07 μM Compound: 16	Cytotoxicity against human A549 cells after 72 hrs by MTT assay Cytotoxicity against human A549 cells after 72 hrs by MTT assay	[PMID: 28011202]
HT-29	IC₅₀	0.08 μM Compound: 16	Cytotoxicity against human HT-29 cells after 72 hrs by MTT assay Cytotoxicity against human HT-29 cells after 72 hrs by MTT assay	[PMID: 28011202]
MKN-45	IC₅₀	0.22 μM Compound: 16	Cytotoxicity against human MKN45 cells after 72 hrs by MTT assay Cytotoxicity against human MKN45 cells after 72 hrs by MTT assay	[PMID: 28011202]

体外実験

c-met-IN-1 (compound 16) exhibits high selectivity and remarkable cytotoxicity against HT-29, MKN-45 and A549 cells with IC₅₀ values of 0.08 μM, 0.22 μM and 0.07 μM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 2084836-84-8
分子量 640.70
分子式 C₃₅H₃₇FN₆O₅
SMILES

FC1=CC(NC(C2=CN(C3=C(OC)C=CC=C3)C=N2)=O)=CC=C1OC4=CC=NC5=CC(OCCCN6CCN(C)CC6)=C(OC)C=C54
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (266 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Wang X, et al. Design, synthesis and biological evaluation of novel 4-(2-fluorophenoxy)quinoline derivatives as selective c-Met inhibitors. Bioorg Med Chem. 2017 Feb 1;25(3):886-896. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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