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MID2 - midline 2 Gene

Also Known as FXY2; RNF60; TRIM1; MRX101; XLID101

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 11043

About MID2

Cytogenetic location: Xq22.3 Genomic coordinates (GRCh38): X:107,825,735-107,931,637 (from NCBI)

This gene has 4 transcripts (splice variants), 204 orthologues, 80 paralogues and is associated with 2 phenotypes. Ubiquitous expression in thyroid (RPKM 3.8), fat (RPKM 3.4) and 24 other tissues.

Summary

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to microtubular structures in the cytoplasm. Alternate splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Feb 2009]

MID2 Products (4)

mRNA	Protein	Name
NM_001382751.1	NP_001369680.1	probable E3 ubiquitin-protein ligase MID2 isoform 3
NM_001382752.1	NP_001369681.1	probable E3 ubiquitin-protein ligase MID2 isoform 4
NM_012216.4	NP_036348.2	probable E3 ubiquitin-protein ligase MID2 isoform 1
NM_052817.3	NP_438112.2	probable E3 ubiquitin-protein ligase MID2 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables enzyme binding	IPI IPI: Inferred from physical interaction	11806752	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables microtubule binding	IMP IMP: Inferred from mutant phenotype	11806752	GOA
enables phosphoprotein binding	IPI IPI: Inferred from physical interaction	11806752	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	11806752	GOA
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	23077300	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in innate immune response	IDA IDA: Inferred from direct assay	18248090	GOA
involved in negative regulation of viral entry into host cell	IDA IDA: Inferred from direct assay	18248090	GOA
involved in negative regulation of viral transcription	IDA IDA: Inferred from direct assay	18248090	GOA
involved in positive regulation of DNA-binding transcription factor activity	IMP IMP: Inferred from mutant phenotype	23077300	GOA
involved in positive regulation of NF-kappaB transcription factor activity	IMP IMP: Inferred from mutant phenotype	23077300	GOA
involved in positive regulation of autophagy	IMP IMP: Inferred from mutant phenotype	26347139	GOA
involved in positive regulation of canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	23077300	GOA
involved in protein localization to microtubule	IMP IMP: Inferred from mutant phenotype	11806752	GOA
involved in suppression of viral release by host	IDA IDA: Inferred from direct assay	18248090	GOA

Cellular Component GO Annotation	Evidence	References	Source
colocalizes with microtubule	IDA IDA: Inferred from direct assay	10400986	GOA
located in microtubule	IDA IDA: Inferred from direct assay	11806752	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MID2 Protein Structure

zf-C3HC4_3

zf-B_box

SPRY

0
200
400
600
735 a.a.

Protein Preferred Names	Protein Names
probable E3 ubiquitin-protein ligase MID2	RING finger protein 60

Related Diseases

Diseases	Alias
Intellectual Developmental Disorder, X-Linked 101	XLID101 Mental Retardation, X-Linked 101 Mrx101 Mental Retardation, X-Linked, Type 101
Non-Syndromic X-Linked Intellectual Disability	X-Linked Non-Syndromic Intellectual Disability Non-Specific X-Linked Mental Retardation X-Linked Non-Specific Intellectual Disability
Opitz Gbbb Syndrome	Opitz G/Bbb Syndrome Opitz Syndrome Hypertelorism-Hypospadias Syndrome Hypertelorism With Esophageal Abnormality And Hypospadias Opitz-Frias Syndrome Os Osx Telecanthus-Hypospadias Syndrome Opitz Gbbb Syndrome Type I Opitz Bbbg Syndrome Hypospadias-Dysphagia Syndrome Opitz Bbb/G Syndrome GBBB Opitz Gbbb Syndrome, X-Linked Opitz Syndrome, X-Linked Opitz Gbbb Syndrome, Type I, Formerly Gbbb1, Formerly Opitz-G Syndrome, Type I, Formerly Ogs1, Formerly Opitz Bbbg Syndrome, Type I, Formerly Bbbg1, Formerly Bbb Syndrome G Syndrome Gbbb Syndrome Hypertelorism Hypospadias Syndrome Hypospadias-Dysphagia, Syndrome Opitz-G Syndrome, Type 2 Telecanthus With Associated Abnormalities Hypertelorism With Esophageal Abnormalities And Hypospadias Hypertelorism-Hypospadias Sydrome Opitz Bbb Syndrome Opitz G Syndrome Hypertelorism-Oesophageal Abnormality-Hypospadias Syndrome Opitz Gbbb Syndrome 1 GBBB1 Bbbg1 Gggb1 Opitz Bbbg Syndrome Type I Opitz Gbbb Syndrome X-Linked Opitz-G Syndrome Type I Opitz Syndrome X-Linked Opitz G Syndrome, Type I Opitz Bbbg Syndrome, Type I
Hypospadias	Hypospadias Familial Familial Hypospadias
Non-Syndromic X-Linked Intellectual Disability 63	Acsl4-Related Intellectual Disability Mrx63 Mrx68 X-Linked Mental Retardation 68
Non-Syndromic X-Linked Intellectual Disability 101	Mrx101 X-Linked Mental Retardation 101
Myringitis Bullosa Hemorrhagica	Bullous Myringitis
Non-Syndromic X-Linked Intellectual Disability 30	Mrx30 Mrx47 X-Linked Mental Retardation 30/47 X-Linked Mental Retardation 47 Mental Retardation, X-Linked, Type 30/47
Tetanus Neonatorum	Neonatal Tetanus NNT Trismus Neonatorum Newborn Trismus
Opitz-Kaveggia Syndrome	Fg Syndrome Fgs1 Fgs Keller Syndrome OKS Fg Syndrome 1 Fg Syndrome Type 1 Mental Retardation, Large Head, Imperforate Anus, Congenital Hypotonia, And Partial Agenesis Of Corpus Callosum Intellectual Disability, Large Head, Imperforate Anus, Congenital Hypotonia, And Partial Agenesis Of Corpus Callosum Mental Retardation, Large Head, Imperforate Anus, Congenital Hypotonia, And Partial Agenesis Of The Corpus Callosum
Urinary Schistosomiasis	Schistosoma Haematobium Infection Schistosoma Hematobium Infection Schistosomiasis Due To Schistosoma Haematobium Bladder Schistosomiasis Cystitis With Bilharziasis Schistosoma Haematobium Schistosoma Hematobium Infectious Disease Schistosomiasis Of Bladder Vesical Schistosomiasis Schistosomiasis Urinary Schistosomiasis Haematobia Genitourinary Bilharziasis Genitourinary Tract Schistosomiasis Schistosomiasis Due To Schistosoma Haematobium [Urinary Schistosomiasis] Haematochyluria In Schistosomiasis Infection Due To Schistosoma Matthei
Strabismus	Strabismus, Susceptibility To Strabismus, Susceptibility To, 1 Strabismus 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-W854844A	(E)-JP-2-196 TFA	Ligand	97.89%	Unkown
HY-RS08436	MID2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	MID2	VGNC	VGNC:43224
Mus musculus	MID2	MGD	MGI:1344333
Macaca mulatta	MID2	VGNC	VGNC:74722
Rattus norvegicus	MID2	RGD	RGD:1565674
Bos taurus	MID2	VGNC	VGNC:106822
Felis catus	MID2	VGNC	VGNC:68256
Others	MID2	NCBI