Apoc3 - apolipoprotein C3 Gene

Also Known as ApoC-III; apo-CIII

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24207

Summary

Predicted to enable high-density lipoprotein particle receptor binding activity; Lipase Inhibitor activity; and phospholipid binding activity. Involved in several processes, including lipoprotein transport; negative regulation of oxidative phosphorylation; and positive regulation of triglyceride biosynthetic process. Located in extracellular space. Used to study hyperthyroidism; hypothyroidism; and type 1 diabetes mellitus. Biomarker of cholestasis. Human ortholog(s) of this gene implicated in several diseases, including Apolipoprotein C-III deficiency; chronic kidney disease; coronary artery disease; familial hyperlipidemia (multiple); and glucose metabolism disease (multiple). Orthologous to human apoC3 (Apolipoprotein C3). [provided by Alliance of Genome Resources, Apr 2022]

Apoc3 Products (2)

mRNA Protein Name
NM_001271053.1 NP_001257982.1 apolipoprotein C-III precursor
NM_012501.2 NP_036633.2 apolipoprotein C-III precursor

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in cellular response to glucose stimulus IDA
IDA: Inferred from direct assay
21183731 RGD
involved in lipoprotein transport IDA
IDA: Inferred from direct assay
4020294 RGD
involved in negative regulation of oxidative phosphorylation IDA
IDA: Inferred from direct assay
11177239 RGD
involved in positive regulation of triglyceride biosynthetic process IMP
IMP: Inferred from mutant phenotype
23542898 RGD
involved in response to fatty acid IEP
IEP: Inferred from expression pattern
20938723 RGD
involved in response to nutrient IEP
IEP: Inferred from expression pattern
7811230 RGD
involved in response to peptide hormone IDA
IDA: Inferred from direct assay
8429259 RGD
involved in response to triglyceride IEP
IEP: Inferred from expression pattern
6698975 RGD
involved in response to vitamin A IEP
IEP: Inferred from expression pattern
7811230 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
9888873 RGD
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
6419747 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

apolipoprotein C-III

  • apolipoprotein C-3

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-145727A Volanesorsen sodium Inhibitor 98.51% Unkown
HY-164740A Plozasiran sodium Inhibitor 97.94% Unkown
HY-153491 Olezarsen Inhibitor 96.60% Unkown
HY-164740 Plozasiran Inhibitor 99.00% Unkown

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-145727 Volanesorsen Inhibitor 97.97% Phase 3
HY-153491A Olezarsen sodium Inhibitor 96.53% Phase 3

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00846 APOC3 Human Pre-designed siRNA Set A Inhibitor / Unkown
Bioactive MoleculesInhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P992470 STT-5058 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Apoc3 NCBI NCBI:345
Mus musculus Apoc3 NCBI NCBI:11814