2. Metabolic Enzyme/Protease
  3. Apolipoprotein
  4. STT-5058

STT-5058  (Synonyms: ARGX-116; NN5058)

Cat. No.: HY-P992470
Technical Support

STT-5058 (ARGX-116; NN5058) is a human monoclonal antibody targeting ApoC3 and belongs to the class of ApoC3 inhibitors. STT-5058 exhibits pH-dependent circulation properties and binds to a unique epitope on ApoC3. STT-5058 reduces triglyceride levels and accelerates the clearance of atherogenic remnant lipoproteins containing ApoC3. STT-5058 can be used in research related to hypertriglyceridemia, dyslipidemia and cardiovascular diseases.

For research use only. We do not sell to patients.

STT-5058

STT-5058 Chemical Structure

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STT-5058 Related Antibodies

Top Publications Citing Use of Products

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apoE apoB apoA1 apoA2 apoA4 apoC1 apoC2 apoC3

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Description

STT-5058 (ARGX-116; NN5058) is a human monoclonal antibody targeting ApoC3 and belongs to the class of ApoC3 inhibitors. STT-5058 exhibits pH-dependent circulation properties and binds to a unique epitope on ApoC3. STT-5058 reduces triglyceride levels and accelerates the clearance of atherogenic remnant lipoproteins containing ApoC3. STT-5058 can be used in research related to hypertriglyceridemia, dyslipidemia and cardiovascular diseases[1].

Species Reactivity

Human
IC50 & Target[1]

apoC3

 

In Vitro

STT-5058 binds to unique and novel epitopes on apolipoprotein C3 (ApoC3), blocks ApoC3 function, and shows pH-dependent recycling properties to mediate the clearance of ApoC3-containing lipoproteins in vitro[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

STT-5058 Related Antibodies
Gene ID

345  [NCBI]

Accession

P02656
Target

ApoC3
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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STT-5058 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

STT-5058ARGX-116 NN5058STT5058STT 5058ARGX116ARGX 116NN5058NN 5058NN-5058ApolipoproteinApolipoprotein C3ApoC3-containing atherogenic particlestriglycerideatherogenic remnant lipoproteinshypertriglyceridemiaApoC3Inhibitorinhibitorinhibit

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