TCS1105
Based on 1 Customer Validation
TCS1105 is a benzodiazepine ligand with agonist for α2-subunit containing GABAA receptors and antagonist for α1-subunit containing GABAA receptors. TCS1105 reduces anxiety-like behavior in mice. TCS1105 enhances offensive behavior and social dominance. TCS1105 blocks Sema3A induced AGC (axonal growth cones) collapse in a concentration-dependent fashion.
For research use only. We do not sell to patients.
- Purity: 99.44%
- CAS No.: 185391-33-7
- Formula: C17H13FN2O2
- Molecular Weight:296.30
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Chemical Information
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CAS No. 185391-33-7
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Appearance Solid
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Molecular Weight 296.30
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Formula C17H13FN2O2
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Color White to off-white
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SMILES
O=C(NCC1=CC=C(F)C=C1)C(C2=CNC3=C2C=CC=C3)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 100 mg/mL (337.50 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. van der Kooij MA, et al. GABAA receptors in the ventral tegmental area control the outcome of a social competition in rats. Neuropharmacology. 2018 Aug;138:275-281. [Content Brief]
[2]. Xu J, et al. Anesthetics disrupt growth cone guidance cue sensing through actions on the GABAA α2 receptor mediated by the immature chloride gradient. Neurotoxicol Teratol. 2019 Jul-Aug;74:106812. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.3750 mL | 16.8748 mL | 33.7496 mL | 84.3739 mL |
| 5 mM | 0.6750 mL | 3.3750 mL | 6.7499 mL | 16.8748 mL | |
| 10 mM | 0.3375 mL | 1.6875 mL | 3.3750 mL | 8.4374 mL | |
| 15 mM | 0.2250 mL | 1.1250 mL | 2.2500 mL | 5.6249 mL | |
| 20 mM | 0.1687 mL | 0.8437 mL | 1.6875 mL | 4.2187 mL | |
| 25 mM | 0.1350 mL | 0.6750 mL | 1.3500 mL | 3.3750 mL | |
| 30 mM | 0.1125 mL | 0.5625 mL | 1.1250 mL | 2.8125 mL | |
| 40 mM | 0.0844 mL | 0.4219 mL | 0.8437 mL | 2.1093 mL | |
| 50 mM | 0.0675 mL | 0.3375 mL | 0.6750 mL | 1.6875 mL | |
| 60 mM | 0.0562 mL | 0.2812 mL | 0.5625 mL | 1.4062 mL | |
| 80 mM | 0.0422 mL | 0.2109 mL | 0.4219 mL | 1.0547 mL | |
| 100 mM | 0.0337 mL | 0.1687 mL | 0.3375 mL | 0.8437 mL |
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