2-PMPA sodium
Based on 6 publication(s) in Google Scholar
2-PMPA (2-(Phosphonomethyl)pentanedioic acid) sodium is a glutamate carboxypeptidase II (GCPII) inhibitor with an IC50 of 0.0003 μM. 2-PMPA sodium shows low blood-brain barrier penetration. 2-PMPA sodium blocks the hydrolysis of NAAG, regulates glutamate levels in the brain and neurovascular coupling. 2-PMPA sodium is applicable to the research of neurological diseases.
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- Pureté: 99.9%
- CAS No.: 373645-42-2
- Formule: C6H7Na4O7P
- Masse moléculaire:314.05
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Stockage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
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Publications Citing Use of MedChemExpress (MCE) 2-PMPA sodium
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Flow Cytometry
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Histological Imaging/Staining
Activité biologique
IC50: 300 pM (GCPII)[1]
2-PMPA sodium remains stable in rat plasma when stored at room temperature for 4 h, subjected to 3 freeze-thaw cycles, stored at -80°C for 28 days, and placed in a 10°C autosampler for 18 h[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
2-PMPA (80 mg/kg; i.p.; single dose) sodium exerts no significant effects on motor coordination or cognitive ability in Swiss-Webster mice within 24 hours[1].
2-PMPA (100 mg/kg; intraperitoneal injection; single dose) sodium is rapidly absorbed in male Wistar rats, with low brain penetration (a brain/plasma AUC0-t ratio of 0.018), while it shows higher penetration in peripheral nerve tissues[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Swiss-Webster (SW) (male, approx 6-8 wk old)[2]
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Dosage:80 mg/kg
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Administration:i.p.; single dose
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Result:Showed mean latency to fall not significantly different from control mice at all tested time points (70, 240, 420, 1440 min post-administration).
Caused no impairment in motor coordination or cognitive ability observed over the 24-h period.
Chemical Information
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CAS No. 373645-42-2
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Appearance Solid
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Masse moléculaire 314.05
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Formule C6H7Na4O7P
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Color White to off-white
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SMILES
O=C(O[Na])C(CP(O[Na])(O[Na])=O)CCC(O[Na])=O
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Synonyms
2-(Phosphonomethyl)pentanedioic acid sodium
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (6)
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Journal Impact Factor
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Most Recent
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ACS Nano
Metabolic Control by Heat Stress Determining Cell Fate to Ferroptosis for Effective Cancer Therapy. [Abstract]2021 Apr 27;15(4):7179-7194. PMID: 33861924
2-PMPA sodium purchased from MedChemExpress. Usage Cited in: ACS Nano. 2021 Apr 27;15(4):7179-7194. [Abstract]
After incubation with 2-PMPA (0.5 mM; 6 h), the uptake of Fluoro-GBP@Fe3O4 (50 μg Fe/mL) in C4-2 cells was assessed by flow cytometry.
2-PMPA sodium purchased from MedChemExpress. Usage Cited in: ACS Nano. 2021 Apr 27;15(4):7179-7194. [Abstract]
2-PMPA (0.5 μM; i.v.; 1-6 h) obviously inhibited the gradual aggregation of GBP@Fe3O4 at the tumor sites in C4-2 tumor-bearing mice.
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J Med Chem
Synthesis, Preclinical Evaluation, and First-in-Human PET Study of Quinoline-Containing PSMA Tracers with Decreased Renal Excretion. [Abstract]2021 Apr 8;64(7):4179-4195. PMID: 33783213 -
Pharmaceuticals (Basel)
Characterization of Non-Specific Uptake and Retention Mechanisms of [177Lu]Lu-PSMA-617 in the Salivary Glands. [Abstract]2023 May 3;16(5):692. PMID: 37242475 -
Biochem Biophys Res Commun
2020 Dec 17;533(4):1393-1399. PMID: 33092792 -
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Solvant et solubilité
H2O : 33.33 mg/mL (106.13 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (277 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Baslow MH, et al. 2-PMPA, a NAAG peptidase inhibitor, attenuates magnetic resonance BOLD signals in brain of anesthetized mice: evidence of a link between neuron NAAG release and hyperemia. J Mol Neurosci. 2005;26(1):1-15. [Content Brief]
[2]. Rais R, et al. Bioanalytical method for evaluating the pharmacokinetics of the GCP-II inhibitor 2-phosphonomethyl pentanedioic acid (2-PMPA). J Pharm Biomed Anal. 2014;88:162-169. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 3.1842 mL | 15.9210 mL | 31.8421 mL | 79.6052 mL |
| 5 mM | 0.6368 mL | 3.1842 mL | 6.3684 mL | 15.9210 mL | |
| 10 mM | 0.3184 mL | 1.5921 mL | 3.1842 mL | 7.9605 mL | |
| 15 mM | 0.2123 mL | 1.0614 mL | 2.1228 mL | 5.3070 mL | |
| 20 mM | 0.1592 mL | 0.7961 mL | 1.5921 mL | 3.9803 mL | |
| 25 mM | 0.1274 mL | 0.6368 mL | 1.2737 mL | 3.1842 mL | |
| 30 mM | 0.1061 mL | 0.5307 mL | 1.0614 mL | 2.6535 mL | |
| 40 mM | 0.0796 mL | 0.3980 mL | 0.7961 mL | 1.9901 mL | |
| 50 mM | 0.0637 mL | 0.3184 mL | 0.6368 mL | 1.5921 mL | |
| 60 mM | 0.0531 mL | 0.2654 mL | 0.5307 mL | 1.3268 mL | |
| 80 mM | 0.0398 mL | 0.1990 mL | 0.3980 mL | 0.9951 mL | |
| 100 mM | 0.0318 mL | 0.1592 mL | 0.3184 mL | 0.7961 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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