3-Ethoxybenzamide
Based on 1 Customer Validation
3-Ethoxybenzamide is an alkoxybenzamide compound with antibacterial activity and a FtsZ inhibitor that can cross the blood-brain barrier. 3-Ethoxybenzamide distributes widely and rapidly in vivo, rapidly reaches equilibrium between various tissues and blood, and is linearly taken up by hepatocytes. 3-Ethoxybenzamide is completely dependent on hepatic microsomal oxidation for clearance, with salicylamide as its major metabolite. 3-Ethoxybenzamide can be used for the study of bacterial infections.
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- CAS No.: 55836-69-6
- Formule: C9H11NO2
- Masse moléculaire:165.19
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Stockage:
Store at room temperature 3 years.
In solvent -80°C, 2 years , -20°C, 1 year
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
In Vitro
3-Ethoxybenzamide (0.1-1.0 mM; 0.5-10 min) rapidly reaches equilibrium with rat erythrocytes, and its whole blood-plasma partition coefficient equals 1 at all tested concentrations[1].
3-Ethoxybenzamide undergoes deethylation in rat liver microsomes, with the corrected kinetic parameter being Vmax1=0.124 μmol/min/g[1].
3-Ethoxybenzamide (500-2000 μg/mL) inhibits the bacterial growth of Bacillus subtilis 168, with an MIC of 2000 μg/mL, and induces cell division inhibition at a concentration of 500 μg/mL[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Staphylococcus aureus, Bacillus subtilis 168
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Concentration:500-2000 μg/mL
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Incubation Time:/
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Result:Against Staphylococcus aureus and Bacillus subtilis 168 with MIC of 1024 μg/mL and 2000 μg/mL, respectively.
In Vivo
3-Ethoxybenzamide (20-100 mg/kg; i.v.; single bolus) simulated plasma and tissue concentrations in healthy 250 g rats show reasonable agreement with observed values across 20 mg/kg, 50 mg/kg, and 100 mg/kg intravenous bolus doses, with minor discrepancies in small intestine and muscle tissue profiles[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:albino (male, 1.7-2.3 kg)[1]
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Dosage:10 mg/kg; 20 mg/kg; 80 mg/kg
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Administration:i.v.; single bolus
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Result:Showed very good agreement between simulated and observed plasma concentrations at 10 mg/kg and 20 mg/kg doses.
Systemically higher observed plasma concentrations than simulated values in the terminal elimination phase at 80 mg/kg dose.
Showed general agreement between simulated and observed tissue concentrations in brain, kidney, and liver at 20 mg/kg dose, despite some variability in measured tissue levels.
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Animal Model:250 g body weight[1]
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Dosage:20 mg/kg; 50 mg/kg; 100 mg/kg
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Administration:i.v.; single bolus
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Result:Predicted observed rat plasma data reasonably well with simulated plasma concentration-time profiles at 20 mg/kg, 50 mg/kg, and 100 mg/kg doses.
Showed reasonable agreement between simulated and observed tissue concentrations in most tissues (brain, lung, liver, kidney, muscle, skin, adipose) at 20 mg/kg dose.
Overestimated peak levels in simulated small intestine concentrations and showed a delayed peak not seen in observed data in simulated muscle concentrations at 20 mg/kg dose.
Chemical Information
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CAS No. 55836-69-6
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Appearance Solid
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Masse moléculaire 165.19
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Formule C9H11NO2
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Color White to off-white
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SMILES
O=C(N)C=1C=CC=C(OCC)C1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Store at room temperature 3 years
In solvent -80°C 2 years -20°C 1 year
Pureté et documentation
Références
[1]. Lin JH, et al. Physiological pharmacokinetics of ethoxybenzamide based on biochemical data obtained in vitro as well as on physiological data. J Pharmacokinet Biopharm. 1982;10(6):649-661. [Content Brief]
[2]. Czaplewski LG, et al. Antibacterial alkoxybenzamide inhibitors of the essential bacterial cell division protein FtsZ. Bioorg Med Chem Lett. 2009;19(2):524-527. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
3-Ethoxybenzamide Related Classifications
HY-W237019 Related Classifications
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