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Cat. No.: HY-100295

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(4-Acetamidocyclohexyl) nitrate

(Synonyms: BM121307)

(4-Acetamidocyclohexyl) nitrate (BM121307) is a guanylate cyclase activator.

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CAS No.: 137213-91-3
Formule: C₈H₁₄N₂O₄
Masse moléculaire:202.21

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

(4-Acetamidocyclohexyl) nitrate Chemical Structure

CAS No.: 137213-91-3

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vivo
Chemical Information
Protocole
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

(4-Acetamidocyclohexyl) nitrate (BM121307) is a guanylate cyclase activator.

In Vivo

The elimination of BM121307 and its metabolites via urine and feces amount to 76.5% after oral application, and to 80.7% of the applied dose after intravenous application. The major amount of radioactivity is eliminated via urine (69.4% and 73.6% of the dose, respectively), whereas the fecal elimination is found to be negligible. Investigations of the urinary samples show that the drug is metabolized to a high percentage trans-N-(4-Hydroxycyclohexyl) acetamide is the main metabolite; 73% of the radioactive compounds (after p.o.-administration and 69% after intravenous application could be identified as the alcohol of BM121307; the amounts of the drug totaled 9% and 13%, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 137213-91-3
Masse moléculaire 202.21
Formule C₈H₁₄N₂O₄
SMILES

CC(N[C@@H]1CC[C@@H](O[N+]([O-])=O)CC1)=O
Synonyms

BM121307
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocole

Animal Administration^[1]

Dogs^[1]

The biotransformation of BM121307 in the dog is examined after oral and intravenous administration. For that purpose, the organic nitrate is synthesized as radioactive [¹⁴C]- and as [¹³C]-labeled compounds. The defined isotopic mixture is administered to the dogs. Within the examined period of 168 h, the elimination of BM121307 is measured^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Zell C, et al. Biotransformation of the organic nitrate trans-N-(4-nitroxycyclohexyl)acetamide in dogs. Arzneimittelforschung. 1994 Sep;44(9):1021-8. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

(4-Acetamidocyclohexyl) nitrate

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Activité biologique
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Chemical Information
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Références

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(4-Acetamidocyclohexyl) nitrate

Vericiguat

Linaclotide

Riociguat

Cinaciguat

BAY 41-2272

Lificiguat

Nelociguat

NS-2028

Vericiguat (Standard)

Cinaciguat hydrochloride

Praliciguat

Riociguat (Standard)

Activité biologique

Chemical Information

Protocole

Pureté et documentation

Références

Calculators

Help & FAQs

(4-Acetamidocyclohexyl) nitrate

Vericiguat

Linaclotide

Riociguat

Cinaciguat

BAY 41-2272

Lificiguat

Nelociguat

NS-2028

Vericiguat (Standard)

Cinaciguat hydrochloride

Praliciguat

Riociguat (Standard)

Activité biologique

Chemical Information

Protocole

Pureté et documentation

Références

Calculators

Help & FAQs

(4-Acetamidocyclohexyl) nitrate Related Classifications

HY-100295 Related Classifications