A-74273
A-74273 is an orally active peptide renin inhibitor (IC50=3.1 nM). A-74273 competitively binds to the active site of renin, preventing angiotensinogen from being converted to ANG-I, thereby reducing the level of angiotensin II. A-74273 can be used in the study of diseases such as hypertension.
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- CAS No.: 130316-95-9
- Formule: C44H74N4O8
- Masse moléculaire:787.08
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
Chemical Information
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CAS No. 130316-95-9
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Masse moléculaire 787.08
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Formule C44H74N4O8
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SMILES
CCCC[C@H](O[C@H](C(N1CCC(OCOC)CC1)=O)CC2=CC=CC=C2)C(NC(C(O)C[C@H](C(NCCCN3CCOCC3)=O)C(C)C)CC4CCCCC4)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocole
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Research Protocol for Cardiovascular Diseases
Cardiovascular disease can be modeled as maladaptive cardiac remodeling, where ischemic injury or pressure overload activates inflammatory signaling, fibroblast activation, extracellular-matrix deposition, cardiomyocyte hypertrophy, vascular remodeling, and progressive ventricular dysfunction. The TGF-β/SMAD axis is a central profibrotic pathway after myocardial injury and pressure overload, while innate immune and cytokine pathways regulate leukocyte recruitment, scar formation, and adverse remodeling. Key unresolved questions include which inflammatory signals are reparative versus harmful, when fibrosis is protective versus maladaptive, and whether pathway inhibition improves function without weakening necessary infarct healing or compensatory remodeling.
Pureté et documentation
Références
[1]. Dayton, et al. Effects of angiotensinase inhibitors on plasma protein binding and IC50 determinations of renin inhibitors. Clinical chemistry 38.11 (1992): 2239-2243. [Content Brief]
[2]. Kleinert, et al. "Discovery of a well-absorbed, efficacious renin inhibitor, A-74273." Hypertension 20.6 (1992): 768-775. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
A-74273 Related Classifications
HY-129412 Related Classifications
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