Abyssinone V
Abyssinone V is a prenylated flavonoid with predicted anti-viral activity. Abyssinone V can be isolated from the stem bark of Erythrina melanacantha. Abyssinone V possesses good pharmacodynamics properties. Abyssinone V is predicted to be antivirals including anti-herpes (HSV) agent, with mechanisms comprising inhibition of polymerase, ATPase and membrane integrity.
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- CAS No.: 77263-11-7
- Formule: C25H28O5
- Masse moléculaire:408.49
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Activité biologique
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Cell Line
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Type | Value | Description | References |
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| HL-60 | IC50 |
6 μM
Compound: 1, Abyssinone V
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Inhibition of PLA2 in fMLP and A23187 ionophore-stimulated human HL60 cells assessed as effect on [3H]arachidonic acid release
Inhibition of PLA2 in fMLP and A23187 ionophore-stimulated human HL60 cells assessed as effect on [3H]arachidonic acid release
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10.1021/np960533e |
| PC-3M | CC50 |
17 μM
Compound: (S)-3, abyssinone III
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Cytotoxicity in human PC3M cells assessed as inhibition of cell proliferation after 3 days by MTT assay
Cytotoxicity in human PC3M cells assessed as inhibition of cell proliferation after 3 days by MTT assay
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[PMID: 21116437] |
Chemical Information
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CAS No. 77263-11-7
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Masse moléculaire 408.49
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Formule C25H28O5
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SMILES
O=C1C(C(O[C@H](C(C=C2C/C=C(C)/C)=CC(C/C=C(C)/C)=C2O)C1)=CC(O)=C3)=C3O
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Koch K, et al. Abyssinone V, a prenylated flavonoid isolated from the stem bark of Erythrina melanacantha increases oxidative stress and decreases stress resistance in Caenorhabditis elegans. J Pharm Pharmacol. 2019 Jun;71(6):1007-1016. [Content Brief]
[2]. Kwofie SK, et al. Identification of novel potential inhibitors of varicella-zoster virus thymidine kinase from ethnopharmacologic relevant plants through an in-silico approach. J Biomol Struct Dyn. 2022;40(23):12932-12947. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Abyssinone V Related Classifications
HY-N8265 Related Classifications
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