ALK-IN-24
ALK-IN-24 is an orally active ALK inhibitor with an IC50 value of 1.7 nM. ALK-IN-24 also inhibits insulin receptor kinase with an IC50 value of 6 nM. ALK-IN-24 suppresses the proliferation of lung adenocarcinoma cells. ALK-IN-24 inhibits ALK-driven tumor growth in xenograft mouse models. ALK-IN-24 can be used in research related to non-small cell lung cancer.
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- CAS No.: 2093414-37-8
- Formule: C26H30ClN7O3S
- Masse moléculaire:556.08
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
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Help & FAQs
Activité biologique
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| NCI-H3122 | TGI |
86.3 %
Compound: 29
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Antitumor activity against human NCI-H3122 cells xenografted in BALB/c nu/nu mouse assessed as tumor growth inhibition at 50 mg/kg administered once daily via oral gavage for 14 days measured twice weekly during compound dosing relative to control
Antitumor activity against human NCI-H3122 cells xenografted in BALB/c nu/nu mouse assessed as tumor growth inhibition at 50 mg/kg administered once daily via oral gavage for 14 days measured twice weekly during compound dosing relative to control
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[PMID: 28385505] |
ALK-IN-24 (Compound 6) inhibits wild-type ALK and ALKL1196M mutant kinases in the HTRF KinEASE-TK enzymatic assay, with IC50 values of 1.7 nM and 8.1 nM, respectively[1].
ALK-IN-24 inhibits insulin receptor kinase with an IC50 of 6.0 nM in the HTRF KinEASE-TK enzymatic activity assay[1].
ALK-IN-24 inhibits the proliferation of H3122 cells in cell-based proliferation assays, with a CC50 of 36 nM[1].
ALK-IN-24 inhibits the proliferation of BaF3 cells expressing ALKL1196M in cell-based proliferation assays, with a CC50 of 120 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:SCID mice (8 mice per group)[1]
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Dosage:50 mg/kg
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Administration:p.o.; daily; 14 days
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Result:Achieved a tumor growth inhibition (TGI) rate of 86.3% during the 14-day treatment period.
Showed slow tumor regrowth after treatment discontinuation.
Caused no changes in body weight or side effects during the study.
Chemical Information
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CAS No. 2093414-37-8
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Masse moléculaire 556.08
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Formule C26H30ClN7O3S
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SMILES
O=S(=O)(C=1C=CC=CC1NC2=NC(=NC=C2Cl)NC=3C=C4C(=CC3OC)N5C(=NN(C)CC5)CC4)C(C)C
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ALK-IN-24 Related Classifications
HY-153503 Related Classifications
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