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Cat. No.: HY-126017

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Aminopyridine 2

Aminopyridine 2 is an irreversible, selective, and orally active myeloperoxidase (MPO) inhibitor, with an IC₅₀ of 0.16 μM and a K_i of 24 μM against human MPO. Aminopyridine 2 is applicable to research on chronic inflammatory diseases.

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CAS No.: 2411643-58-6
Formule: C₁₃H₁₃BrN₄O
Masse moléculaire:321.18

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Please store the product under the recommended conditions in the Certificate of Analysis.

Aminopyridine 2 Chemical Structure

CAS No.: 2411643-58-6

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vitro
- Parmacokinetics
- In Vivo
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Voir tous les produits spécifiques à Isoform Glutathione Peroxidase :

GPX1
GPX4

In Vitro

Aminopyridine 2 (2 h) inhibits the activity of human MPO in plasma, with an apparent IC₅₀ of 1.9 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	C_max	T_max	AUC_0-∞	Bioavailability
Mice^[1]	10 mg/kg	p.o.	11884 nM	1.3 h	58440 nM·h/mL	51 %
Rat^[1]	10 mg/kg	p.o.	20844 nM	0.4 h	133162 nM·h/mL	~100 %
Dog^[1]	10 mg/kg	p.o.	19486 nM	2.3 h	335615 nM·h/mL	~100 %

In Vivo

Aminopyridine 2 (2.5-100 mg/kg; p.o.; single administration) dose-dependently inhibits MPO activity in a mouse peritonitis model^[1].
Aminopyridine 2 (~50-200 mg/kg; mixed with diet for 14 days) dose-dependently inhibits MPO activity in a mouse peritonitis model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C57BL/6J (male, 8 weeks old)^[1]
Dosage:

2.5 mg/kg; 25 mg/kg; 50 mg/kg; 100 mg/kg
Administration:

i.g.; single dose
Result:

Reduced residual plasma MPO activity by 24% at 2.5 mg/kg, 62% at 25 mg/kg, 74% at 50 mg/kg, and 86% at 100 mg/kg, measured 5 hours post-dose.
Caused dose-dependent inhibition of 3-chlorotyrosine accumulation in peritoneal exudate.
Achieved an apparent in vivo IC₅₀ of 1.4 μM for inhibition of plasma MPO activity.

Chemical Information

CAS No. 2411643-58-6
Masse moléculaire 321.18
Formule C₁₃H₁₃BrN₄O
SMILES

O=C(NC1=CC=C(Br)C=C1)NCC2=CN=C(N)C=C2
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Marro ML, et al. Discovery of 1-((6-Aminopyridin-3-yl)Methyl)-3-(4-Bromophenyl)Urea as a Potent, Irreversible Myeloperoxidase Inhibitor. J Pharmacol Exp Ther. 2018;367(1):147-154. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Activité biologique
- Description
- In Vitro
- In Vivo
Chemical Information
Pureté et documentation
Références

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Aminopyridine 2

Voir tous les produits spécifiques à Isoform Glutathione Peroxidase

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

Aminopyridine 2 Related Classifications

HY-126017 Related Classifications