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United States

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Cat. No.: HY-157217

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Antitumor agent-99

Antitumor agent-99 (compound 7) is an anticancer agent targeting FRα/β and PCFT. Antitumor agent-99 inhibits R2/PCFT4 (PCFT), RT16(FRα), and D4(FRβ) cells with IC₅₀s of 51.46 nM, 2.53 nM, and 2.98 nM, respectively.

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Formule: C₁₉H₂₁N₅O₆S
Masse moléculaire:447.46

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Antitumor agent-99 Chemical Structure

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Antibody-Drug Conjugates

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target

Folate receptor (FR) α, FRβ, Pproton-coupled folate transporter (PCFT)^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
IGROV-1	IC₅₀	2.52 nM Compound: 7	Antiproliferative activity against human IGROV-1 cells assessed as inhibition of cell growth incubated for 96 hrs by CellTiter-Blue cell viability assay Antiproliferative activity against human IGROV-1 cells assessed as inhibition of cell growth incubated for 96 hrs by CellTiter-Blue cell viability assay	[PMID: 38116433]
KB	IC₅₀	3.43 nM Compound: 7	Antiproliferative activity against human KB cells assessed as cell growth inhibition incubated for 96 hrs by CellTiter-Blue cell viability assay Antiproliferative activity against human KB cells assessed as cell growth inhibition incubated for 96 hrs by CellTiter-Blue cell viability assay	[PMID: 38116433]

Chemical Information

Masse moléculaire 447.46
Formule C₁₉H₂₁N₅O₆S
SMILES

O=C(N[C@H](C(O)=O)CCC(O)=O)C1=CC=C(CCC2=C(C)NC(N=C(N3)N)=C2C3=O)S1
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Kaku K et al. Discovery of Tumor-Targeted 6-Methyl Substituted Pemetrexed and Related Antifolates with Selective Loss of RFC Transport[J]. ACS Medicinal Chemistry Letters, 2023.

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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