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Arcapillin

Arcapillin is a flavonoid that can be isolated from Artemisia capillaris Thunb. Arcapillin induces dose-dependent relaxation of ileum and pulmonary artery smooth muscle, causes slight urinary bladder smooth muscle contraction at highest tested concentrations. Arcapillin binds to the active site of SARS-CoV-2 M_pro via interactions with Gln139, His163, and His164, exhibits antiviral activity against SARS-CoV-2 and MERS-CoV. Arcapillin can be used for the research of gastrointestinal disorders, COVID-19, and Middle East respiratory syndrome (MERS).

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CAS No.: 83162-82-7
Formule: C₁₈H₁₆O₈
Masse moléculaire:360.31

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

Arcapillin Chemical Structure

CAS No.: 83162-82-7

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Bioz

Activité biologique

Description

IC₅₀ & Target

PTP1B^[1]

In Vitro

Arcapillin binds to the SARS-CoV-2 main protease (PDB: 7L0D) with a docking score of -6.16 kcal mol⁻¹, indicating favorable interactions with the enzyme's active site^[2].
Arcapillin (72 h) exhibits antiviral activity against SARS-CoV-2 in Vero E6 cells with an IC₅₀ of 190.8 μg mL⁻¹, and has a low cytotoxic profile in the same cell line with a CC₅₀ of 1228 μg mL⁻¹, yielding a selectivity index of 6.40^[2].
Arcapillin (72 h) exhibits potent antiviral activity against MERS-CoV in Vero E6 cells with an IC₅₀ of 16.58 μg mL⁻¹, and has a CC₅₀ of 54.17 μg mL⁻¹ in the same cell line, yielding a selectivity index of 3.26^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 83162-82-7
Masse moléculaire 360.31
Formule C₁₈H₁₆O₈
SMILES

O=C1C=C(C2=CC(OC)=C(O)C=C2O)OC3=CC(OC)=C(OC)C(O)=C13
Structure Classification
- Flavonoids
- Flavones
Initial Source
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Abu-Niaaj L, et al. Evaluation of Antispasmodic Effect of Arcapillin on Smooth Muscles of Rats. Pharmacogn J. 2019 July 15;11(4):712-717.

[2]. Badawy AM, et al. Dual SARS-CoV-2 and MERS-CoV inhibitors from Artemisia monosperma: isolation, structure elucidation, molecular modelling studies, and in vitro activities. Org Biomol Chem. 2024 Aug 28;22(34):7006-7016. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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