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Cat. No.: HY-111287

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Autophagonizer

(Synonyms: DK-1-49)

Autophagonizer (DK-1-49) is a small molecule autophagy inducer that results in an accumulation of autophagy-associated LC3-II and enhances levels of autophagosomes and acidic vacuoles. Autophagonizer inhibits cell viability and induces cell death in not only cancer cells but also Bax/Bak double-knockout cells with EC₅₀ values of 3-4 μM.

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CAS No.: 853136-76-2
Formule: C₂₈H₃₁N₅O₃S₂
Masse moléculaire:549.71

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

Autophagonizer Chemical Structure

CAS No.: 853136-76-2

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Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Cellular Effect

Cell Line	Type	Value	Description	References
HeLa	EC₅₀	1.3 μM Compound: DK-1-49	Induction of autophagy in human HeLa cells assessed as accumulation of acidic vacuoles after 24 hrs by MDC/Hoechst 33342 staining based fluorescence assay Induction of autophagy in human HeLa cells assessed as accumulation of acidic vacuoles after 24 hrs by MDC/Hoechst 33342 staining based fluorescence assay	[PMID: 27597252]
HeLa	EC₅₀	3.5 μM Compound: DK-1-49	Induction of autophagic cell death in human HeLa cells after 24 hrs by MTT assay Induction of autophagic cell death in human HeLa cells after 24 hrs by MTT assay	[PMID: 27597252]
HeLa	EC₅₀	3.5 μM Compound: DK-1-49	Induction of autophagy in human HeLa cells assessed as autophagosome formation after 24 hrs by Cyto-ID reagent/ Hoechst 33342 staining based fluorescence assay Induction of autophagy in human HeLa cells assessed as autophagosome formation after 24 hrs by Cyto-ID reagent/ Hoechst 33342 staining based fluorescence assay	[PMID: 27597252]
MEF	EC₅₀	2.1 μM Compound: DK-1-49	Induction of autophagic cell death in wild-type MEF after 24 hrs by MTT assay Induction of autophagic cell death in wild-type MEF after 24 hrs by MTT assay	[PMID: 27597252]
MEF	EC₅₀	2.2 μM Compound: DK-1-49	Induction of autophagic cell death in Bax/Bak double knockout MEF after 24 hrs by MTT assay Induction of autophagic cell death in Bax/Bak double knockout MEF after 24 hrs by MTT assay	[PMID: 27597252]

Chemical Information

CAS No. 853136-76-2
Masse moléculaire 549.71
Formule C₂₈H₃₁N₅O₃S₂
SMILES

O=C(C1=COC(CSC2=NC3=C(C4=C(CCCC4)S3)C(N2CC5=CC=CC=C5)=O)=N1)NCCN6CCCC6
Synonyms

DK-1-49
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Nguyen J, et al. Facile synthesis of autophagonizer and evaluation of its activity to induce autophagic cell death in apoptosis-defective cell line. Bioorg Med Chem Lett. 2016 Oct 1;26(19):4753-4756. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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