BAY-386
BAY-386, a chemical probe, is a PAR-1 antagonist that inhibits the expression of pro-inflammatory factors MCP-1 and CXCL1 in HUVEC.
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- CAS No.: 1256941-06-6
- Formule: C22H25F3N4O5S
- Masse moléculaire:514.52
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
IC50 & Target
PAR-1, CXCL1[1]
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Platelet | IC50 |
>100 μM
Compound: EUB0000291
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Inhibition of platelet aggregation (human plasma, ADP, Collagen)
Inhibition of platelet aggregation (human plasma, ADP, Collagen)
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10.6019/CHEMBL4507269 |
| Platelet | IC50 |
0.14 μM
Compound: EUB0000291
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Inhibition of platelet aggregation (human plasma, thrombin)
Inhibition of platelet aggregation (human plasma, thrombin)
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10.6019/CHEMBL4507269 |
| Platelet | IC50 |
0.43 μM
Compound: EUB0000291
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Inhibition of platelet aggregation (human plasma, TRAP-6) (IC50)
Inhibition of platelet aggregation (human plasma, TRAP-6) (IC50)
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10.6019/CHEMBL4507269 |
Chemical Information
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CAS No. 1256941-06-6
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Masse moléculaire 514.52
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Formule C22H25F3N4O5S
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SMILES
O=C(N1C[C@@H](C2=NC(C3CC3)=NO2)C[C@@H](C4=CC=C(OC(F)(F)F)C=C4)C1)N5CCS(CC5)(=O)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BAY-386 Related Classifications
HY-120544 Related Classifications
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