BMS-961955
BMS-961955 is an orally active inhibitor of HCV NS5B polymerase. BMS-961955 exhibits potent inhibitory activity against HCV genotype 1 (GT-1a/1b) replicons with EC50s of 4.3 nM and 7.9 nM, respectively. BMS-961955 can be used for the study of HCV infection.
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- CAS No.: 1431328-92-5
- Formule: C37H43FN4O4S
- Masse moléculaire:658.83
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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- Pureté et documentation
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Help & FAQs
Activité biologique
Description
Parmacokinetics
| Species | Dose | Route | T1/2 | Vss | CL | AUC0-24 | F |
|---|---|---|---|---|---|---|---|
| Dog[1] | 1 mg/kg | i.v. | 12.2 h | 0.6 L/kg | 0.8 mL/min/kg | 25.7 μM·h | / |
| Dog[1] | 3 mg/kg | p.o. | / | / | / | 62.1 μM·h | 84 % |
| Monkey[1] | 1 mg/kg | i.v. | 8.7 h | 3.1 L/kg | 10.5 mL/min/kg | 2.3 μM·h | / |
| Monkey[1] | 3 mg/kg | p.o. | / | / | / | 3.1 μM·h | 48 % |
| Rat[1] | 10 mg/kg | p.o. | / | / | / | 12.4 μM·h | 52 % |
| Rat[1] | 5 mg/kg | i.v. | 6.2 h | 3.9 L/kg | 10 mL/min/kg | 12.3 μM·h | / |
Chemical Information
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CAS No. 1431328-92-5
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Masse moléculaire 658.83
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Formule C37H43FN4O4S
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SMILES
CN1CC(CC2)N(C([C@@]34CN5C(C(C=CC(F)=C6)=C6[C@]3([H])C4)=C(C7CCCCC7)C8=C5C=C(C(NS(=O)(C9(C)CC9)=O)=O)C=C8)=O)C2C1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BMS-961955 Related Classifications
HY-102030 Related Classifications
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