DS-22-inf-021
DS-22-inf-021 is a neuraminidase (NA) inhibitor. DS-22-inf-021 has antiviral activity against influenza viruses.
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- CAS No.: 945170-74-1
- Formule: C20H23N3O2
- Masse moléculaire:337.42
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
In Vitro
DS-22-inf-021 inhibits NA activity of IBV (B/Samara/32/2018 Yamagata lineage) and resistant IAV A/Vladivostok/2/2009 (H1N1 pdm09) carrying the H275Y mutation, with IC50 values of 9.1 μM and 14.7 μM, respectively[1].
DS-22-inf-021 (0.5-50 μM, 10 h) shows antiviral activity in MDCK cells were infected with IAV and IBV strains[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:8-week-old female BALB/c mice, intranasally inoculated with 50 μL of five 50 % mouse lethal doses of IAV and IBV[1].
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Dosage:20, 50 and 100 mg/kg
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Administration:After 2 h post-infection, i.p. injection
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Result:Reached 85 % protection at 100 mg/kg dose. For the B/Samara/32/2018 strain, it was observed that 100 % of mice treated with DS-22-inf-021 at 100 mg/kg.
Chemical Information
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CAS No. 945170-74-1
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Masse moléculaire 337.42
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Formule C20H23N3O2
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SMILES
O=C(NC1=CC=C(NC(C2=CC=CC=C2)=O)C=C1)NC3CCCCC3
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DS-22-inf-021 Related Classifications
HY-163364 Related Classifications
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