Fenchyl alcohol
Based on 1 Customer Validation
Fenchyl alcohol is a monoterpene alcohol that can be used as a fragrance. Fenchyl alcohol has antifungal activity and can inhibit the formation of biofilms and hyphae of Candida albicans. Fenchyl alcohol also has a strong inhibitory effect on the rumen microbial activity of sheep and deer.
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- Pureté : 97.0%
- CAS No.: 1632-73-1
- Formule: C10H18O
- Masse moléculaire:154.25
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Stockage:Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
In Vitro
Fenchyl alcohol has a strong inhibitory effect on rumen microbial activity and inhibits rumen microbial fermentation activity[1].
Fenchyl alcohol (0.005-0.01%; 4-24 h) inhibits the formation of Candida albicans biofilm and hyphae, and inhibits the metabolism of biofilm cells [2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
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Cell Line:C. albicans cells
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Concentration:0.01%
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Incubation Time:4 h
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Result:Significantly downregulated the expression of ECE1, ECE2, and RBT1.
In Vivo
In rats treated with Fenchyl alcohol (2.05, 2.56, 3.2, 4.0, and 5.0 g/kg, orally, single-dose, observed for 14 days), all rat deaths occurred between days 1 and 3. At the 2.05 and 2.56 g/kg doses, half of the animals died; at 3.2 g/kg, three-thirds died; at 4.0 g/kg, two-half died; and at 5.0 g/kg, all five-fifths died[4].
Fenchyl alcohol is administered topically at a dose of 2.0 g/kg body weight, and observed for 14 days. No deaths occurred in either of the two guinea pigs in the experimental group[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1632-73-1
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Appearance <43°C Solid,>46°C Liquid
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Masse moléculaire 154.25
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Formule C10H18O
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Color Colorless to light yellow
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SMILES
OC1C(C2)(C)CCC2C1(C)C
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvant et solubilité
In Vitro:
DMSO : 50 mg/mL (324.15 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Ethanol : 40 mg/mL (259.32 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (278 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Oh HK, et al. Effect of Various Essential Oils Isolated from Douglas Fir Needles upon Sheep and Deer Rumen Microbial Activity. Appl Microbiol. 1967 Jul;15(4):777-84. [Content Brief]
[2]. Manoharan RK, et al. Antibiofilm and Antihyphal Activities of Cedar Leaf Essential Oil, Camphor, and Fenchone Derivatives against Candida albicans. Front Microbiol. 2017 Aug 3;8:1476. [Content Brief]
[3]. Api AM, et al. RIFM fragrance ingredient safety assessment, Fenchyl alcohol, CAS registry number 1632-73-1. Food Chem Toxicol. 2015 Oct;84 Suppl:S25-32. [Content Brief]
[4]. Bhatia SP, et al. Fragrance material review on fenchyl alcohol. Food Chem Toxicol. 2008 Nov;46 Suppl 11:S157-9. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| Ethanol / DMSO | 1 mM | 6.4830 mL | 32.4149 mL | 64.8298 mL | 162.0746 mL |
| 5 mM | 1.2966 mL | 6.4830 mL | 12.9660 mL | 32.4149 mL | |
| 10 mM | 0.6483 mL | 3.2415 mL | 6.4830 mL | 16.2075 mL | |
| 15 mM | 0.4322 mL | 2.1610 mL | 4.3220 mL | 10.8050 mL | |
| 20 mM | 0.3241 mL | 1.6207 mL | 3.2415 mL | 8.1037 mL | |
| 25 mM | 0.2593 mL | 1.2966 mL | 2.5932 mL | 6.4830 mL | |
| 30 mM | 0.2161 mL | 1.0805 mL | 2.1610 mL | 5.4025 mL | |
| 40 mM | 0.1621 mL | 0.8104 mL | 1.6207 mL | 4.0519 mL | |
| 50 mM | 0.1297 mL | 0.6483 mL | 1.2966 mL | 3.2415 mL | |
| 60 mM | 0.1080 mL | 0.5402 mL | 1.0805 mL | 2.7012 mL | |
| 80 mM | 0.0810 mL | 0.4052 mL | 0.8104 mL | 2.0259 mL | |
| 100 mM | 0.0648 mL | 0.3241 mL | 0.6483 mL | 1.6207 mL |
Fenchyl alcohol Related Classifications
HY-N7107 Related Classifications
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