FTO-IN-10
FTO-IN-10 (compound 7) is a potent human demethylase FTO (the fat mass and obesity-associated protein) inhibitor with an IC50 of 4.5 μM. FTO-IN-10 enters the FTO’s structural domain II binding pocket through hydrophobic and hydrogen bonding interactions. FTO-IN-10 induces DNA damage and autophagic cell death in A549 cells.
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- Formule: C22H20N4O3
- Masse moléculaire:388.42
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Help & FAQs
Activité biologique
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
2.8 μM
Compound: 7
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Antiproliferative activity against human A549 cells assessed as inhibition of cell growth
Antiproliferative activity against human A549 cells assessed as inhibition of cell growth
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[PMID: 37974948] |
| NB-4 | IC50 |
1.5 μM
Compound: 7
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Antiproliferative activity against human NB4 cells assessed as inhibition of cell growth
Antiproliferative activity against human NB4 cells assessed as inhibition of cell growth
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[PMID: 37974948] |
Chemical Information
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Masse moléculaire 388.42
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Formule C22H20N4O3
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SMILES
O=C(NC1=CC2=CC=CC(C(N(CCN(C)C)C3=O)=O)=C2C3=C1)C4=NC=CC=C4
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
FTO-IN-10 Related Classifications
HY-156405 Related Classifications
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