L-Balenine
L-Balenine is an orally active Pin1 inhibitor and intracellular pH buffer. L-Balenine enhances the phagocytic activity of macrophages, and promotes the expression of pro-inflammatory and anti-inflammatory cytokines during muscle degeneration. L-Balenine also upregulates the expression of myogenic marker genes associated with regeneration, thereby effectively driving skeletal muscle regeneration. L-Balenine can be widely used in studies related to skeletal muscle injury and its repair mechanisms.
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- CAS No.: 331-38-4
- Formule: C10H16N4O3
- Masse moléculaire:240.26
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
L-Balenine (10 mM; 24 h) dose-dependently enhances the phagocytic activity of RAW264.7 macrophage cells[1].
L-Balenine (10 mM; 24 h) significantly enhances the phagocytic uptake of opsonized E. coli BioParticles by RAW264.7 macrophage cells, increasing bead uptake per cell to 2.38 times the control level[1].
L-balenine (2-4 mM; 60 seconds) potently and specifically inhibits the PPIase catalytic activity of purified recombinant Pin1 in a dose-dependent manner[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6J (male, 6 weeks old at study start, CTX-induced skeletal muscle injury)[1]
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Dosage:1% w/w balenine-enriched extract (containing 27.3% balenine)
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Administration:p.o.; ad libitum; 2 weeks prior to Cardiotoxin (CTX) injection and up to 14 days post-injection
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Result:Increased wet weight of CTX-injected TA muscle significantly compared to normal diet group at day 3 post-CTX injection.
Increased wet weight of CTX-injected TA muscle significantly at day 14 post-CTX injection compared to day 0, with no significant differences between days 0, 3, and 7.
Reduced average cell-to-cell membrane space in TA muscle to approximately 40% of that in normal diet group at day 7 post-CTX injection.
Upregulated relative mRNA expression of Pax7, MyoD1, myogenin, TNF-α, MCP-1, TGF-β1, and IL-10 significantly compared to normal diet group at day 3 post-CTX injection.
Upregulated relative mRNA expression of Myh3 significantly compared to normal diet group at day 7 post-CTX injection.
Chemical Information
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CAS No. 331-38-4
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Masse moléculaire 240.26
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Formule C10H16N4O3
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SMILES
NCCC(N[C@H](C(O)=O)CC1=CN(C)C=N1)=O
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Structure Classification
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Initial Source
Freshwater turtles
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
L-Balenine Related Classifications
HY-N19860 Related Classifications
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