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Cat. No.: HY-P11942

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Lactokinin

Lactokinin is an Endothelin-1 (HY-P0202) release inhibitor and ACE inhibitor, with an ACE IC₅₀ value of 29 μM. Lactokinin binds to bovine β-lactoglobulin variant A to form a non-covalent complex, which delays its hydrolysis by chymotrypsin, as well as by pepsin/chymotrypsin, in vitro. Lactokinin can be used in research related to hypertension.

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CAS No.: 132160-04-4
Formule: C₃₇H₆₄N₁₂O₈S
Masse moléculaire:837.04

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Lactokinin Chemical Structure

CAS No.: 132160-04-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Voir tous les produits spécifiques à Isoform Endothelin Receptor :

ET_A
ET_B

In Vitro

Cardiovascular RegulationRenal RegulationLocal Vascular RegulationOthers

Cardiovascular Regulation

Renal Regulation

Lactokinin inhibits porcine kidney angiotensin-converting enzyme activity with an IC₅₀ of 29 μM^[2].

Local Vascular Regulation

Cardiovascular Regulation

Lactokinin (0.1-1 mM) inhibits basal and thrombin-stimulated endothelin-1 release from cultured porcine aortic endothelial cells, with 1 mM reducing basal release by 29% and 0.1 mM and 1 mM reducing thrombin-stimulated release by 32% and 43%, respectively^[2].

Others

Lactokinin is bound to purified bovine β-lactoglobulin variant A via non-covalent interactions, and the bound peptide is protected from oxidation and ion adduction during ionization compared to free lactokinin^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Research Protocol for Cardiovascular Diseases

Chemical Information

CAS No. 132160-04-4
Masse moléculaire 837.04
Formule C₃₇H₆₄N₁₂O₈S
SMILES

C[C@H](N)C(N[C@@H](CC(C)C)C(N1[C@@H](CCC1)C(N[C@@H](CCSC)C(N[C@H](C(N[C@@H]([C@@H](C)CC)C(N[C@H](C(O)=O)CCCNC(N)=N)=O)=O)CC2=CN=CN2)=O)=O)=O)=O
Sequence

Ala-Leu-Pro-Met-His-Ile-Arg
Sequence Shortening

ALPMHIR
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Roufik S, et al. Physicochemical characterization and in vitro digestibility of β-lactoglobulin/β-Lg f142-148 complexes[J]. International dairy journal, 2007, 17(5): 471-480.

[2]. Maes W, et al. Influence of the lactokinin Ala-Leu-Pro-Met-His-Ile-Arg (ALPMHIR) on the release of endothelin-1 by endothelial cells. Regulatory peptides. 2004 Apr 15;118(1-2):105-9. [Content Brief]

[3]. Pina AS, et al. Studies on the molecular recognition between bioactive peptides and angiotensin-converting enzyme. Journal of molecular recognition : JMR. 2009;22(2):162-8. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

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100 mg

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