Malpinin A
Malpinin A (MBJ-0173) is a dehydrohexapeptide biosurfactant with significant anthelmintic activity. Malpinin A specifically accumulates in the nematode digestive tract, thereby effectively inhibiting nematode feeding and proliferation without causing paralysis. Malpinin A can be used in studies related to plant-parasitic nematode infection.
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- CAS No.: 2097822-76-7
- Formule: C44H62N10O8
- Masse moléculaire:859.03
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Malpinin A (100 μM) shows no significant cytotoxicity against SKOV-3, ACC-MESO-1, or Jurkat cells at a concentration of 100 μM[2].
Malpinin A (10 μg) shows no antibacterial activity against Micrococcus luteus at a dose of 10 μg per disk[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Malpinin A (100 μg mL-1; supplementation of fungal culture media) at 100 μg mL-1 confers nematode protection to M. indohii, significantly reducing Aphelenchus avenae propagation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:unspecified strain (adult hermaphrodites, stage L3−4 larvae)[1]
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Dosage:5.45 μg mL-1 (IC50 concentration); 11.6 μM (2× IC50 concentration); 4× IC50 concentration
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Administration:exposure in culture media
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Result:Exhibited anthelminthic activity with an IC50 of 5.45 μg mL-1.
Killed or nearly immobilized nematodes at 4× IC50, with only very few larvae hatching compared to untreated controls.
Ceased nematode feeding on bacterial food sources without immediately affecting motility.
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Animal Model:unspecified strain[1]
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Dosage:100 μg mL-1
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Administration:supplementation of fungal culture media
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Result:Reduced *Aphelenchus avenae* propagation drastically, with nematode numbers comparable to levels seen in cocultures with *M. alpina* (natural malpinin producer).
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Animal Model:unspecified strain (adult hermaphrodites, larvae)[1]
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Dosage:16.92 μM (malpinin A-FAM, IC50); 110 μM (malpinin A-alkyne, Raman imaging); 31 μM (malpinin A-alkyne, full anthelminthic inhibition)
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Administration:exposure in culture media
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Result:Showed high fluorescence emission originating from the entire digestive tract, including the pharynx and grinder region, in both larvae and adults via malpinin A-FAM imaging.
Distinguished malpinin A-FAM signal from autofluorescence via FLIM, confirming accumulation in the intestinal lumen.
Confirmed accumulation in the pharyngeal lumen, parts of the grinder, and the intestine via alkyne-tagged malpinin A Raman microspectroscopy.
Chemical Information
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CAS No. 2097822-76-7
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Masse moléculaire 859.03
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Formule C44H62N10O8
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Synonyms
MBJ-0173
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Sequence
Ac-d{Leu-Arg-Leu}-Phe-{DHB}-d{Trp}
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Sequence Shortening
Ac-d{LRL}-F-{DHB}-d{Trp}
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Structure Classification
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Initial Source
Mortierella alpina
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Malpinin A Related Classifications
HY-P11862 Related Classifications
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