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Cat. No.: HY-P11862

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Malpinin A

Name: Malpinin A
Brand: MedChemExpress
SKU: HY-P11862
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(Synonyms: MBJ-0173)

Malpinin A (MBJ-0173) is a dehydrohexapeptide biosurfactant with significant anthelmintic activity. Malpinin A specifically accumulates in the nematode digestive tract, thereby effectively inhibiting nematode feeding and proliferation without causing paralysis. Malpinin A can be used in studies related to plant-parasitic nematode infection.

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CAS No.: 2097822-76-7
Formule: C₄₄H₆₂N₁₀O₈
Masse moléculaire:859.03

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Synthèse personnalisée de peptides

Malpinin A Chemical Structure

CAS No.: 2097822-76-7

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Activité biologique
- Description
- In Vitro
- In Vivo
Chemical Information
Pureté et documentation
Références
Calculators
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Activité biologique

Description

In Vitro

Anti-cancerBacterial Infection

Anti-cancer

Malpinin A (100 μM) shows no significant cytotoxicity against SKOV-3, ACC-MESO-1, or Jurkat cells at a concentration of 100 μM^[2].

Bacterial Infection

Malpinin A (10 μg) shows no antibacterial activity against Micrococcus luteus at a dose of 10 μg per disk^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Parasitic Infection

Malpinin A (100 μg mL^-1; supplementation of fungal culture media) at 100 μg mL^-1 confers nematode protection to M. indohii, significantly reducing Aphelenchus avenae propagation^[1].
Malpinin A (5.45 μg mL^-1-4× IC₅₀ concentration; exposure in culture media) potently inhibits C. elegans proliferation and feeding with an IC₅₀ of 6.35 μM, leading to reduced survival and larval hatching at higher doses^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

unspecified strain (adult hermaphrodites, stage L3−4 larvae)^[1]
Dosage:

5.45 μg mL^-1 (IC₅₀ concentration); 11.6 μM (2× IC₅₀ concentration); 4× IC₅₀ concentration
Administration:

exposure in culture media
Result:

Exhibited anthelminthic activity with an IC₅₀ of 5.45 μg mL^-1.
Killed or nearly immobilized nematodes at 4× IC₅₀, with only very few larvae hatching compared to untreated controls.
Ceased nematode feeding on bacterial food sources without immediately affecting motility.

Animal Model:

unspecified strain^[1]
Dosage:

100 μg mL^-1
Administration:

supplementation of fungal culture media
Result:

Reduced *Aphelenchus avenae* propagation drastically, with nematode numbers comparable to levels seen in cocultures with *M. alpina* (natural malpinin producer).

Animal Model:

unspecified strain (adult hermaphrodites, larvae)^[1]
Dosage:

16.92 μM (malpinin A-FAM, IC₅₀); 110 μM (malpinin A-alkyne, Raman imaging); 31 μM (malpinin A-alkyne, full anthelminthic inhibition)
Administration:

exposure in culture media
Result:

Showed high fluorescence emission originating from the entire digestive tract, including the pharynx and grinder region, in both larvae and adults via malpinin A-FAM imaging.
Distinguished malpinin A-FAM signal from autofluorescence via FLIM, confirming accumulation in the intestinal lumen.
Confirmed accumulation in the pharyngeal lumen, parts of the grinder, and the intestine via alkyne-tagged malpinin A Raman microspectroscopy.

Related Protocols :

Chemical Information

CAS No. 2097822-76-7
Masse moléculaire 859.03
Formule C₄₄H₆₂N₁₀O₈
Synonyms

MBJ-0173
Sequence

Ac-d{Leu-Arg-Leu}-Phe-{DHB}-d{Trp}
Sequence Shortening

Ac-d{LRL}-F-{DHB}-d{Trp}
Structure Classification
- Peptides
Initial Source
- Microorganism
Mortierella alpina
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Büttner H, et al. Beneficial Soil Fungus Kills Predatory Nematodes with Dehydropeptides Translocating into the Animal Gut. Journal of the American Chemical Society. 2024 Dec 18;146(50):34702-34710.

[2]. Kawahara T, et al. Novel arginine-containing peptides MBJ-0173 and MBJ-0174 from Mortierella alpina f28740[J]. The Journal of Antibiotics, 2017, 70(2): 226-229.

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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