MC-GGFG-TriPtolide
MC-GGFG-TriPtolide is a peptide-drug conjugate (PDC) composed of a cell-penetrating peptide (MC), a cathepsin-cleavable GGFG peptide linker, and the payload drug Triptolide (HY-32735), and it is used for targeted intracellular delivery.
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- CAS No.: 3086791-83-2
- Formule: C48H58N6O15
- Masse moléculaire:959.01
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Stockage:
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
Chemical Information
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CAS No. 3086791-83-2
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Appearance Solid
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Masse moléculaire 959.01
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Formule C48H58N6O15
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Color Light yellow to yellow
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SMILES
C[C@@]12[C@@]34[C@@]5([C@@](C[C@@]1([H])C6=C(C(OC6)=O)CC2)([H])O5)[C@@H]([C@@]7([C@](O7)([H])[C@]3([H])O4)C(C)C)OC(COCNC(CNC([C@H](CC8=CC=CC=C8)NC(CNC(CNC(CCCCCN9C(C=CC9=O)=O)=O)=O)=O)=O)=O)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvant et solubilité
In Vitro:
DMSO : 100 mg/mL (104.27 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
Pureté et documentation
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Fiche technique (270 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.0427 mL | 5.2137 mL | 10.4274 mL | 26.0685 mL |
| 5 mM | 0.2085 mL | 1.0427 mL | 2.0855 mL | 5.2137 mL | |
| 10 mM | 0.1043 mL | 0.5214 mL | 1.0427 mL | 2.6069 mL | |
| 15 mM | 0.0695 mL | 0.3476 mL | 0.6952 mL | 1.7379 mL | |
| 20 mM | 0.0521 mL | 0.2607 mL | 0.5214 mL | 1.3034 mL | |
| 25 mM | 0.0417 mL | 0.2085 mL | 0.4171 mL | 1.0427 mL | |
| 30 mM | 0.0348 mL | 0.1738 mL | 0.3476 mL | 0.8690 mL | |
| 40 mM | 0.0261 mL | 0.1303 mL | 0.2607 mL | 0.6517 mL | |
| 50 mM | 0.0209 mL | 0.1043 mL | 0.2085 mL | 0.5214 mL | |
| 60 mM | 0.0174 mL | 0.0869 mL | 0.1738 mL | 0.4345 mL | |
| 80 mM | 0.0130 mL | 0.0652 mL | 0.1303 mL | 0.3259 mL | |
| 100 mM | 0.0104 mL | 0.0521 mL | 0.1043 mL | 0.2607 mL |
MC-GGFG-TriPtolide Related Classifications
HY-188016 Related Classifications
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