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Cat. No.: HY-104083

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North-methanocarbathymidine

Name: North-methanocarbathymidine
Brand: MedChemExpress
SKU: HY-104083
Availability: PreOrder

(Synonyms: N-MCT)

North-methanocarbathymidine (N-MCT) is a potent antiviral agent. North-methanocarbathymidine inhibits DNA synthesis. North-methanocarbathymidine demonstrates potent antiviral activity against HSV-1, HSV-2 and KSHV. North-methanocarbathymidine exhibits anticancer activity against colon adenocarcinoma expressing HSV-tk.

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CAS No.: 156126-12-4
Formule: C₁₂H₁₆N₂O₄
Masse moléculaire:252.27

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

North-methanocarbathymidine Chemical Structure

CAS No.: 156126-12-4

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
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Activité biologique

Description

IC₅₀ & Target

^[1]

HSV-1

HSV-2

Voir tous les produits spécifiques à Isoform DNA/RNA Synthesis :

Voir tous les produits spécifiques à Isoform HSV :

Cellular Effect

Cell Line	Type	Value	Description	References
HFF	CC₅₀	>396 μM Compound: 1a	Cytotoxic concentration for 50% inhibition of cell growth of HSV-1 infected HFF cells determined by CPE assay Cytotoxic concentration for 50% inhibition of cell growth of HSV-1 infected HFF cells determined by CPE assay	[PMID: 14584954]
HFF	CC₅₀	>396 μM Compound: 1a	Cytotoxic concentration for 50% inhibition of cell growth of HSV-2 infected HFF cells determined by CPE assay Cytotoxic concentration for 50% inhibition of cell growth of HSV-2 infected HFF cells determined by CPE assay	[PMID: 14584954]
HFF	CC₅₀	>79 μM Compound: 1a	Cytotoxic concentration for 50% inhibition of cell growth of HSV-1 infected HFF cells determined by VPR assay Cytotoxic concentration for 50% inhibition of cell growth of HSV-1 infected HFF cells determined by VPR assay	[PMID: 14584954]
HFF	CC₅₀	>79 μM Compound: 1a	Cytotoxic concentration for 50% inhibition of cell growth of HSV-2 infected HFF cells determined by VPR assay Cytotoxic concentration for 50% inhibition of cell growth of HSV-2 infected HFF cells determined by VPR assay	[PMID: 14584954]
HFF	EC₅₀	0.04 μM Compound: 1a	Inhibitory concentration for HSV-1 plaque reduction (VPR) by 50% in HFF cells Inhibitory concentration for HSV-1 plaque reduction (VPR) by 50% in HFF cells	[PMID: 14584954]
HFF	EC₅₀	0.12 μM Compound: 1a	Inhibitory concentration required to reduce HSV-1 induced cytopathogenic effect (CPE) by 50 % in HFF cells Inhibitory concentration required to reduce HSV-1 induced cytopathogenic effect (CPE) by 50 % in HFF cells	[PMID: 14584954]
HFF	EC₅₀	0.35 μM Compound: 1a	Inhibitory concentration required to reduce HSV-2 induced cytopathogenic effect (CPE) by 50 % in HFF cells Inhibitory concentration required to reduce HSV-2 induced cytopathogenic effect (CPE) by 50 % in HFF cells	[PMID: 14584954]
HFF	EC₅₀	0.47 μM Compound: 1a	Inhibitory concentration for HSV-2 plaque reduction (VPR) by 50% in HFF cells Inhibitory concentration for HSV-2 plaque reduction (VPR) by 50% in HFF cells	[PMID: 14584954]

Chemical Information

CAS No. 156126-12-4
Masse moléculaire 252.27
Formule C₁₂H₁₆N₂O₄
SMILES

O=C1NC(C(C)=CN1[C@@H]2[C@@]3([H])C[C@@]3(CO)[C@@H](O)C2)=O
Synonyms

N-MCT
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Marquez VE, et al. The history of N-methanocarbathymidine: the investigation of a conformational concept leads to the discovery of a potent and selective nucleoside antiviral agent. Antiviral Res. 2006 Sep;71(2-3):268-75. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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