Pleioside A
Pleioside A is a flavonoid glycoside with immunomodulatory activity that is found in the leaves of Pleioblastus amarus. Pleioside A exerts differential regulatory effects on adaptive immune lymphocyte proliferation by inhibiting mouse T cell proliferation and promoting B lymphocyte proliferation. Pleioside A can be used for research on adaptive immunity and immunomodulation.
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- CAS No.: 199925-44-5
- Formule: C24H26O12
- Masse moléculaire:506.46
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Activité biologique
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Activité biologique
Description
In Vitro
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:mouse spleen cells
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Concentration:400 nM, 4 μM, 40 μM
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Incubation Time:48 h
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Result:Inhibited ConA-induced T cell proliferation in a concentration-dependent manner.
At 400 nM, 3H-TdR incorporation was 100.68 × 103 cpm.
At 4 μM, 3H-TdR incorporation decreased to 97.13 × 103 cpm.
At 40 μM, 3H-TdR incorporation decreased further to 90.18 × 103 cpm, representing a marked inhibition compared to the ConA positive control value of 107.24 × 103 cpm.\nStimulated LPS-induced B cell proliferation in a concentration-dependent manner.
At 400 nM, 3H-TdR incorporation was 30.97 × 103 cpm.
At 4 μM, 3H-TdR incorporation increased to 34.35 × 103 cpm.
At 40 μM, 3H-TdR incorporation rose further to 40.87 × 103 cpm, representing a marked stimulation compared to the LPS positive control value of 28.91 × 103 cpm.
- BrdU Incorporation Assay
- Somatic Cell Culture
- CFSE Dye Dilution Proliferation Assay
- Dye-dilution cell tracking and proliferation staining
- CCK-8/WST-8 Cell Proliferation Assay
- Protocol for Cell Cycle
- Cell Counting-Based Growth Curve Assay
- Colony Formation (Clonogenic) Assay
- Research Protocol for Cancer Immunology
- Cell Viability Determination by MTT Colorimetric Assay
- EdU Incorporation Assay (Click Chemistry-Based DNA Synthesis Measurement)
- Ki-67 Immunostaining Proliferation Assay
- PCNA Immunodetection Proliferation Assay
- Protocol for Cell Counting and Cell Density Analysis
- MTT Cell Proliferation Assay
Chemical Information
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CAS No. 199925-44-5
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Masse moléculaire 506.46
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Formule C24H26O12
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SMILES
O=C1C2=C(O)C=C(OC)C=C2OC(C3=CC(OC)=C(C(OC)=C3)O[C@@H]4O[C@@H]([C@H]([C@@H]([C@H]4O)O)O)CO)=C1
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Structure Classification
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pleioside A Related Classifications
HY-N21624 Related Classifications
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