CD228
CD228 corresponds to melanotransferrin, the p97 antigen encoded by the MFI2 gene, a transferrin-homologous iron-binding glycoprotein anchored to the membrane through a GPI moiety. Originally isolated from melanoma cells as p97, it is highly expressed in melanomas and supports iron acquisition and transport, with proposed roles at the blood-brain barrier. CD228 is found in fetal gut and in brain capillary endothelium, while its expression in normal adult melanocytes is far lower than in melanoma, making it a target of interest for melanoma imaging and antibody-based therapy. Its expression has also been reported in lymphomas and other tumors, and MFI2 is used in studies of tumor iron metabolism.
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CD228 Protéines Recombinantes (4)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formule: Human
- Masse moléculaire: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
