QO-83
Based on 1 Customer Validation
QO-83, Retigabine analogue, is a voltage-gated potassium channel KCNQ2 (Kv7.2) activator with an EC50 of 0.56 μM. QO-83 binds to a single hydrophobic pocket of KCNQ2-CaM complex in closed conformation. QO-83 induces a negative shift in the voltage-dependent activation curve of KCNQ2 channels, increasing the channel's voltage sensitivity. QO-83 can be used for the research of epilepsies.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté: 99.58%
- CAS No.: 2253948-15-9
- Formule: C22H25F4N3O
- Masse moléculaire:423.45
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Stockage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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KV7.2 0.56 μM (EC50) |
QO-83 (20 μM; 1 h) binds to a single hydrophobic pocket in the PD (S5-S6 interface) of human KCNQ2-CaM complex in closed conformation, inducing conformational rearrangements of the PD and VSD (S3-S4 interface)[1].
QO-83 (10 μM) shifts the voltage-dependent activation curve negatively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2253948-15-9
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Appearance Solid
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Masse moléculaire 423.45
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Formule C22H25F4N3O
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Color White to off-white
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SMILES
NC1=C(C=CC(NCC2=CC=C(C=C2)C(F)(F)F)=C1F)NC(CCC3CCCC3)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvant et solubilité
DMSO : 50 mg/mL (118.08 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (270 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.3616 mL | 11.8078 mL | 23.6155 mL | 59.0388 mL |
| 5 mM | 0.4723 mL | 2.3616 mL | 4.7231 mL | 11.8078 mL | |
| 10 mM | 0.2362 mL | 1.1808 mL | 2.3616 mL | 5.9039 mL | |
| 15 mM | 0.1574 mL | 0.7872 mL | 1.5744 mL | 3.9359 mL | |
| 20 mM | 0.1181 mL | 0.5904 mL | 1.1808 mL | 2.9519 mL | |
| 25 mM | 0.0945 mL | 0.4723 mL | 0.9446 mL | 2.3616 mL | |
| 30 mM | 0.0787 mL | 0.3936 mL | 0.7872 mL | 1.9680 mL | |
| 40 mM | 0.0590 mL | 0.2952 mL | 0.5904 mL | 1.4760 mL | |
| 50 mM | 0.0472 mL | 0.2362 mL | 0.4723 mL | 1.1808 mL | |
| 60 mM | 0.0394 mL | 0.1968 mL | 0.3936 mL | 0.9840 mL | |
| 80 mM | 0.0295 mL | 0.1476 mL | 0.2952 mL | 0.7380 mL | |
| 100 mM | 0.0236 mL | 0.1181 mL | 0.2362 mL | 0.5904 mL |
QO-83 Related Classifications
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