Sec61-IN-4
Sec61-IN-4 (Compound 16b) is a Sec61 inhibitor (IC50: 0.04 nM in U87-MG cells).
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Formule: C65H111N11O15
- Masse moléculaire:1286.64
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Activité biologique
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Chemical Information
- Pureté et documentation
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Help & FAQs
Activité biologique
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | CC50 |
1.3 nM
Compound: 16b
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Cytotoxicity against human A549 cells assessed as decrease in cell viability incubated for 72 hrs by MTS assay
Cytotoxicity against human A549 cells assessed as decrease in cell viability incubated for 72 hrs by MTS assay
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[PMID: 37849553] |
| HCT-116 | CC50 |
3.4 nM
Compound: 16b
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Cytotoxicity against human HCT-116 cells assessed as decrease in cell viability incubated for 72 hrs by CellTiter-Glo Luminescent Cell Viability Assay
Cytotoxicity against human HCT-116 cells assessed as decrease in cell viability incubated for 72 hrs by CellTiter-Glo Luminescent Cell Viability Assay
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[PMID: 37849553] |
| NHDF | CC50 |
3.9 nM
Compound: 16b
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Cytotoxicity against HDF cells assessed as decrease in cell viability incubated for 72 hrs by CellTiter-Glo Luminescent Cell Viability Assay
Cytotoxicity against HDF cells assessed as decrease in cell viability incubated for 72 hrs by CellTiter-Glo Luminescent Cell Viability Assay
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[PMID: 37849553] |
| U-87MG ATCC | CC50 |
2.2 nM
Compound: 16b
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Cytotoxicity against human U87 cells assessed as decrease in cell viability incubated for 72 hrs by CellTiter-Glo Luminescent Cell Viability Assay
Cytotoxicity against human U87 cells assessed as decrease in cell viability incubated for 72 hrs by CellTiter-Glo Luminescent Cell Viability Assay
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[PMID: 37849553] |
| U-87MG ATCC | IC50 |
0.04 nM
Compound: 16b
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Antiproliferative activity against human U-87 MG cells expressing GLuc assessed as as inhibition of GLuc secretion incubated for 18 hrs by CellTiter-Glo Luminescent Cell Viability Assay
Antiproliferative activity against human U-87 MG cells expressing GLuc assessed as as inhibition of GLuc secretion incubated for 18 hrs by CellTiter-Glo Luminescent Cell Viability Assay
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[PMID: 37849553] |
Chemical Information
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Masse moléculaire 1286.64
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Formule C65H111N11O15
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SMILES
CN(C)[C@H](C(O[C@@H](C(N([C@H](C(N(C)[C@@H](CC(C)C)C(N(C)[C@H](C(N(C)[C@H](C(N(C)[C@@H]([C@@H](C)CC)C(N[C@H](C(N(C)[C@H](C(N[C@H](C1=O)CC2=CC=C(C=C2)OC)=O)CC(C)C)=O)C)=O)=O)COC)=O)[C@H](NC([C@@H](C)N1C)=O)C)=O)=O)COC)C)=O)C(C)C)=O)C(C)C
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Sec61-IN-4 Related Classifications
HY-156349 Related Classifications
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