Cat. No.: HY-138682

STING-IN-2

12 Cited Publications

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Based on 12 publication(s) in Google Scholar

STING-IN-2 (C-170) is a potent and covalent STING inhibitor. STING-IN-2 efficiently inhibits both mouse STING (mmSTING) and human STING (hsSTING). STING-IN-2 can be used for autoinflammatory disease research.

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Pureté: 99.39%
CAS No.: 346691-38-1
Formule: C₁₅H₁₆N₂O₄
Masse moléculaire:288.30

Stockage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year

STING-IN-2 Chemical Structure

CAS No.: 346691-38-1

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Activité biologique
- Description
- In Vitro
Chemical Information
Publications (12)
Solvant et solubilité
- In Vitro
Pureté et documentation
Références
Help & FAQs
Classifications
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Description

In Vitro

THP-1 cells are pretreated with STING-IN-2 (C-170; 0.5 μM) and stimulated with cGAMP. STING-IN-2 (C-170) treatment decreases the IFNB1 and TNF mRNA levels, and also reduces the p-TBK1 levels^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 346691-38-1
Appearance Solid
Masse moléculaire 288.30
Formule C₁₅H₁₆N₂O₄
Color Light yellow to yellow
SMILES

O=C(C1=CC=C([N+]([O-])=O)O1)NC2=CC=C(CCCC)C=C2
Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Publications (12)

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Cell Metab

Innate immune response orchestrates phosphoribosyl pyrophosphate synthetases to support DNA repair. [Abstract]

2021 Oct 5;33(10):2076-2089.e9. PMID: 34343500

STING-IN-2 purchased from MedChemExpress. Usage Cited in: Cell Metab. 2021 Oct 5;33(10):2076-2089.e9. [Abstract]

STING-IN-2 (C-170) (4 mM; 2 h) largely abrogated the phosphorylation of PRPS1/2 T228 in the irradiated FHs 74 Int cells.

STING-IN-2 purchased from MedChemExpress. Usage Cited in: Cell Metab. 2021 Oct 5;33(10):2076-2089.e9. [Abstract]

STING-IN-2 (C-170) (4 mM; 2 h) abolished ionizing radiation-induced PRPS1/2 activity in FHs 74 Int cells.
Adv Mater

A Polymeric mRNA Vaccine Featuring Enhanced Site-Specific mRNA Delivery and Inherent STING-Stimulating Performance for Tumor Immunotherapy. [Abstract]

2025 Apr;37(17):e2410998. PMID: 40095378
Autophagy

Dysfunctional autophagy triggers STING1 activation to exacerbate cartilage degeneration in obesity-associated osteoarthritis. [Abstract]

2025 Aug 6:1-17. PMID: 40728163

STING-IN-2 purchased from MedChemExpress. Usage Cited in: Autophagy. 2025 Aug 6:1-17. [Abstract]

STING-IN-2 (1 μM; 24 h) significantly reduced the level of p-TBK1 in Lv-shAtg7 chondrocytes, a key kinase responsible for STING1 signal transduction.

STING-IN-2 purchased from MedChemExpress. Usage Cited in: Autophagy. 2025 Aug 6:1-17. [Abstract]

Quantification of mRNA levels of Col2a1 and acan in the Lv-shAtg7 chondrocytes treated with STING-IN-2 (1 μM; 24 h).

STING-IN-2 purchased from MedChemExpress. Usage Cited in: Autophagy. 2025 Aug 6:1-17. [Abstract]

STING-IN-2 (1 μM; 24 h) partially abolished the increased phosphorylation levels of MAPK14 (p-MAPK14) and MAP2K3/MKK3 (p-MAP2K3, a MAPK kinase responsible for MAPK14 activation) in Lv-shAtg7 chondrocytes.
Adv Sci (Weinh)

Laparoscopic Delivery of a MnO2-P-ICG Patch for Photodynamic Therapy and NK Cell-Driven Immunotherapy in Hepatocellular Carcinoma. [Abstract]

2026 Jun;13(32):e24246. PMID: 41933937
Adv Sci (Weinh)

Cryoablation Activates the cGAS-STING-CXCL10 Axis in Macrophages to Enhance Anti-Tumor Immunity in NSCLC. [Abstract]

2026 Mar 12:e21931. PMID: 41818612
Adv Sci (Weinh)

Tumor Exosomal ENPP1 Hydrolyzes cGAMP to Inhibit cGAS-STING Signaling. [Abstract]

2024 May;11(20):e2308131. PMID: 38498770
Gut Microbes

CRIg+ macrophages deficiency enhanced inflammation damage in IBD due to gut extracellular vesicles containing microbial DNA. [Abstract]

2024 Jan-Dec;16(1):2379633. PMID: 39024479
EMBO J

Basal IFN-λ2/3 expression mediates tight junction formation in human epithelial cells. [Abstract]

2025 Sep 1. PMID: 40890487
J Transl Med

JUN-ENPP1-cGAS-STING axis mediates immune evasion and tumor progression in bladder cancer. [Abstract]

2025 Nov 4;23(1):1222. PMID: 41188900
Cell Rep

STING-OPTN signaling confers cytoprotection through TBK1-dependent mitophagy. [Abstract]

2026 Jun 9;45(6):117515. PMID: 42268710
Commun Chem

Marine diterpenoid targets STING palmitoylation in mammalian cells. [Abstract]

2023 Jul 18;6(1):153. PMID: 37463995
BMC Microbiol

Lactiplantibacillus plantarum extracellular vesicles exert anti-PEDV effects through STING-dependent autophagy. [Abstract]

2025 May 7;25(1):271. PMID: 40329214

Solvant et solubilité

In Vitro:

DMSO : 100 mg/mL (346.86 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

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Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.4686 mL

17.3430 mL

34.6861 mL

5 mM

0.6937 mL

3.4686 mL

6.9372 mL

10 mM

0.3469 mL

1.7343 mL

3.4686 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (270 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Simone M Haag, et al. Targeting STING with covalent small-molecule inhibitors. Nature. 2018 Jul;559(7713):269-273. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.4686 mL	17.3430 mL	34.6861 mL	86.7152 mL
	5 mM	0.6937 mL	3.4686 mL	6.9372 mL	17.3430 mL
	10 mM	0.3469 mL	1.7343 mL	3.4686 mL	8.6715 mL
	15 mM	0.2312 mL	1.1562 mL	2.3124 mL	5.7810 mL
	20 mM	0.1734 mL	0.8672 mL	1.7343 mL	4.3358 mL
	25 mM	0.1387 mL	0.6937 mL	1.3874 mL	3.4686 mL
	30 mM	0.1156 mL	0.5781 mL	1.1562 mL	2.8905 mL
	40 mM	0.0867 mL	0.4336 mL	0.8672 mL	2.1679 mL
	50 mM	0.0694 mL	0.3469 mL	0.6937 mL	1.7343 mL
	60 mM	0.0578 mL	0.2891 mL	0.5781 mL	1.4453 mL
	80 mM	0.0434 mL	0.2168 mL	0.4336 mL	1.0839 mL
	100 mM	0.0347 mL	0.1734 mL	0.3469 mL	0.8672 mL

Keywords

STING-IN-2

12 Cited Publications

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STING-IN-2

Immunology/Inflammation Compound Library

Small Molecule Immuno-Oncology Compound Library

Covalent Screening Library

Target Protein Ligand Library

Heterocyclic Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Covalent Screening Library Plus

Bioactive Compound Library

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High-Throughput Bioactive Compound Library

Publications Citing Use of MedChemExpress (MCE) STING-IN-2

Activité biologique

Chemical Information

Publications (12)

Solvant et solubilité

Pureté et documentation

Références

Help & FAQs

Complete Stock Solution Preparation Table

STING-IN-2

Immunology/Inflammation Compound Library

Small Molecule Immuno-Oncology Compound Library

Covalent Screening Library

Target Protein Ligand Library

Heterocyclic Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Covalent Screening Library Plus

Bioactive Compound Library

Protein Kinase Compound Library

High-Throughput Bioactive Compound Library

Publications Citing Use of MedChemExpress (MCE) STING-IN-2

Activité biologique

Chemical Information

Publications (12)

Solvant et solubilité

Pureté et documentation

Références

Help & FAQs

Complete Stock Solution Preparation Table

STING-IN-2 Related Classifications

HY-138682 Related Classifications