SWQIGGN
SWQIGGN is an oligopeptide targeting ovarian cancer cells. SWQIGGN inhibits the viability, proliferation, migration, invasion and cell adhesion of ovarian cancer cells and promotes apoptosis. SWQIGGN reduces ascites volume and tumor nodule formation in mouse models. SWQIGGN can be used in studies related to ovarian cancer.
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- Formule: C33H48N10O11
- Masse moléculaire:760.79
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
SWQIGGN specifically binds to human ovarian cancer cell line HO8910, but does not bind to normal human ovarian epithelial cell line OSE[2].
SWQIGGN (10 μM; 1-7 days) significantly reduces the viability of human ovarian cancer HO8910 cells[2].
SWQIGGN (48 h) potently inhibits the invasive ability of human ovarian cancer HO8910 cells in vitro[2].
SWQIGGN (48 h) potently inhibits the migration of human ovarian cancer HO8910 cells in vitro[2].
SWQIGGN (for 5 days) significantly reduces the in vitro adhesion ability of human ovarian cancer HO8910 cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:human ovarian cancer HO8910 cells
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Concentration:10 μM
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Incubation Time:1, 2, 3, 4, 5, 6 and 7 days
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Result:Showed no significant difference in cell viability compared to controls on days 1 and 2.
Significantly reduced HO8910 cell viability compared to control groups from day 3 to day 6, with absorbance values at 492 nm consistently lower in the SWQIGGN group.
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Cell Line:human ovarian cancer HO8910 cells
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Concentration:10 μM
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Incubation Time:48 h
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Result:Inhibited invasion, reducing the average number of invading cells by more than 50% compared to controls.
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Cell Line:human ovarian cancer HO8910 cells
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Concentration:10 μM
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Incubation Time:48 h
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Result:Potently inhibited migration, reducing the average number of migrating cells by more than 80% compared to controls.
Chemical Information
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Masse moléculaire 760.79
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Formule C33H48N10O11
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Sequence
Ser-Trp-Gln-Ile-Gly-Gly-Asn
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Sequence Shortening
SWQIGGN
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Hulin-Curtis SL, et al. Identification of folate receptor α (FRα) binding oligopeptides and their evaluation for targeted virotherapy applications. Cancer gene therapy. 2020 Nov;27(10-11):785-798. [Content Brief]
[2]. Zhou C, et al. Phage display screening identifies a novel peptide to suppress ovarian cancer cells in vitro and in vivo in mouse models. BMC cancer. 2015 Nov 10;15:889. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SWQIGGN Related Classifications
HY-P11854 Related Classifications
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