Triosephosphate isomerase
Based on 1 Customer Validation
Triosephosphate isomerase (TPI) is a biocatalyst that interconverts dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. Triosephosphate isomerase utilises Glu167 as catalytic base, mediates proton shuttling, and stabilises a cis-enediolate intermediate via loop-6 and loop-7 closure to shield its catalytic site. Triosephosphate isomerase can be used for the research of triosephosphate isomerase deficiency.
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- CAS No.: 9023-78-3
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
In Vitro
Triosephosphate isomerase efficiently catalyzes the stereospecific isomerization of DHAP to D-GAP, with a kcat of ~500 s-1; the kcat for the reverse reaction catalyzed by this enzyme is 5,000 s-1[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
Essai clinique
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
EC Number
5.3.1.1
Specific Activity
≥10000 U/mg protein
Unit Definition
One unit is defined as the amount of enzyme that will convert 1.0 μmole D-glyceraldehyde 3- phosphate to dihydroxyacetone phosphate per min at pH 7.6 at 25°C.
Chemical Information
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CAS No. 9023-78-3
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Appearance Solid
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Color White to off-white
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SMILES
[Triosephosphate isomerase]
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Synonyms
TPI
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
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Fiche technique (263 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instruction de manipulation (2659 KB)
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Triosephosphate isomerase Related Classifications
HY-P2931 Related Classifications
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