1012327-63-7
1012327-63-7
Chemical Structure
PX-866-17OH
- CAS No.: 1012327-63-7
- Formula:C29H37NO8
- Molecular Weight:527.61
IUPAC Name: (4S,4aR,5R,6aS,7S,9aR,E)-1-((diallylamino)methylene)-7,11-dihydroxy-4-(methoxymethyl)-4a,6a-dimethyl-2,10-dioxo-1,2,4,4a,5,6,6a,7,8,9,9a,10-dodecahydroindeno[4,5-h]isochromen-5-yl acetate
InChIKey: STKVQJOXRFVEDM-DATHZOKXSA-N
SMILES: C[C@@]12C3=C(C(C(O)=C1/C(C(O[C@@H]2COC)=O)=C\N(CC=C)CC=C)=O)[C@@]4([H])[C@](C[C@H]3OC(C)=O)([C@H](CC4)O)C
Biological Activity: PX-866-17OH is the metabolite of PX-866 (Sonolisib, HY-N6775) and a pan-isoform inhibitor of PI3K with IC50s of 14, 57, 131, and 148 nM against PI3Kα, PI3Kβ, PI3K , and PI3Kδ, respectively[1].
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PX-866-17OH | PX-866-17OH is the metabolite of PX-866 (Sonolisib, HY-N6775) and a pan-isoform inhibitor of PI3K with IC50s of 14, 57, 131, and 148 nM against PI3Kα, PI3Kβ, PI3K , and PI3Kδ, respectively. | |||||||||||||||||||||
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