1017574-88-7
1017574-88-7
Chemical Structure
MK-8712
- CAS No.: 1017574-88-7
- Formula:C12H20N4O5S
- Molecular Weight:332.38
InChIKey: AWYIBQKIKNJPFA-AEJSXWLSSA-N
SMILES: O=S(O)(N1[C@@]2([H])[C@](C1=O)([H])N(CC2)C(N[C@H]3CCCNCC3)=O)=O
Biological Activity: MK-8712 is a bridged monobactam β-lactamase inhibitor that is effective against class C β-lactamases (such as AmpC) but ineffective against class A KPC enzymes. MK-8712 can be used for research on bacterial infections[1][2][3][4].
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MK-8712 | MK-8712 is a bridged monobactam β-lactamase inhibitor that is effective against class C β-lactamases (such as AmpC) but ineffective against class A KPC enzymes. MK-8712 can be used for research on bacterial infections. | |||||||||||||||||||||
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References
- [1]. Blizzard TA, et al. Discovery of MK-7655, a β-lactamase inhibitor for combination with Primaxin®. Bioorganic & medicinal chemistry letters. 2014 Feb 1;24(3):780-5.
- [2]. Farina D, et al. The inhibition of extended spectrum β-lactamases: hits and leads. Curr Med Chem. 2014;21(12):1405-34.
- [3]. Van Den Bossche B. SYNTHESIS OF 3, 4-PYRROLIDINE-FUSED BICYCLIC β-LACTAMS AS POTENTIAL β-LACTAMASE INHIBITORS[D]. Ghent University, 2020.
- [4]. EMILIA D I M E R. Molecular Tools for Drug Resistant Bacteria Detection and Novel Therapeutics for Cancer Treatment and Regenerative Medicine[D].
