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Cat. No.: HY-186351

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MK-8712

MK-8712 is a bridged monobactam β-lactamase inhibitor that is effective against class C β-lactamases (such as AmpC) but ineffective against class A KPC enzymes. MK-8712 can be used for research on bacterial infections.

For research use only. We do not sell to patients.

CAS No.: 1017574-88-7
Formula: C₁₂H₂₀N₄O₅S
Molecular Weight:332.38

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (289 KB)

MK-8712 Chemical Structure

CAS No.: 1017574-88-7

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

^[1]

AmpC

All Beta-lactamase Isoforms :

In Vitro

Bacterial Infection

MK-8712 exhibits a synergistic effect when used in combination with Imipenem (HY-B1369A) and can be used for bacterial infection research^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1017574-88-7
Molecular Weight 332.38
Formula C₁₂H₂₀N₄O₅S
SMILES

O=S(O)(N1[C@@]2([H])[C@](C1=O)([H])N(CC2)C(N[C@H]3CCCNCC3)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (289 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Blizzard TA, et al. Discovery of MK-7655, a β-lactamase inhibitor for combination with Primaxin®. Bioorganic & medicinal chemistry letters. 2014 Feb 1;24(3):780-5.

[2]. Farina D, et al. The inhibition of extended spectrum β-lactamases: hits and leads. Curr Med Chem. 2014;21(12):1405-34.

[3]. Van Den Bossche B. SYNTHESIS OF 3, 4-PYRROLIDINE-FUSED BICYCLIC β-LACTAMS AS POTENTIAL β-LACTAMASE INHIBITORS[D]. Ghent University, 2020.

[4]. EMILIA D I M E R. Molecular Tools for Drug Resistant Bacteria Detection and Novel Therapeutics for Cancer Treatment and Regenerative Medicine[D].

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

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100 mg

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Amount: USD 0.00

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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MK-8712

All Beta-lactamase Isoforms

Biological Activity

Description

IC50 & Target

In Vitro

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

MK-8712 Related Classifications

HY-186351 Related Classifications

Bioz

Keywords

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