1021869-59-9
1021869-59-9
Chemical Structure
AqF026
- CAS No.: 1021869-59-9
- Formula:C20H19ClN2O5S
- Molecular Weight:434.89
InChIKey: MXHXLONRCSGSEY-UHFFFAOYSA-N
SMILES: O=C(C1=CC(S(=O)(NCC2=CC=CC=C2)=O)=C(C=C1NCC3=CC=CO3)Cl)OC
Biological Activity: AqF026 is an aquaporin 1 (AQP1) agonist. AqF026 enhances the channel activity of human AQP1 in the Xenopus laevis oocyte system. AqF026 enhances the osmotic transport of water across the peritoneum in a mouse model of peritoneal dialysis. AqF026 can be used in studies related to ultrafiltration failure in peritoneal dialysis[1][2].
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AqF026 | 99.05% | AqF026 is an aquaporin 1 (AQP1) agonist. AqF026 enhances the channel activity of human AQP1 in the Xenopus laevis oocyte system. AqF026 enhances the osmotic transport of water across the peritoneum in a mouse model of peritoneal dialysis. AqF026 can be used in studies related to ultrafiltration failure in peritoneal dialysis. | ||||||||||||||||||||
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References
- [1]. Yool AJ, et al. AqF026 is a pharmacologic agonist of the water channel aquaporin-1. J Am Soc Nephrol. 2013 Jun;24(7):1045-52. [Content Brief]
- [2]. Berliner JA, et al. Aquaporin-4 expression and modulation in a rat model of post-traumatic syringomyelia. Sci Rep. 2023;13(1):9662. Published 2023 Jun 14. [Content Brief]
Keywords
